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Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain
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Richards, Mark W., O'Regan, Laura, Roth, Daniel, Montgomery, Jessica M., Straube, Anne, Fry, Andrew M. and Bayliss, Richard (2015) Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain. Biochemical Journal, 467 (3). pp. 529-536. doi:10.1042/BJ20150039 ISSN 0264-6021.
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WRAP-microtubule-EML-proteins-oncoprotein-terminal-domain-Straube-2015.pdf - Accepted Version - Requires a PDF viewer. Download (1646Kb) | Preview |
Official URL: http://doi.org/10.1042/BJ20150039
Abstract
We present crystal structures of a trimeric coiled-coil domain found in echinoderm microtubule (MT)-associated protein (EMAP)-like (EML) proteins. This trimerization domain (TD) mediates self-association and interactions between a subset of EML proteins. MT-association of EML proteins requires the TD and an adjacent basic region.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Crystals -- Structure, Microtubules, Tubulins | ||||||||||||||||||
| Journal or Publication Title: | Biochemical Journal | ||||||||||||||||||
| Publisher: | Portland Press | ||||||||||||||||||
| ISSN: | 0264-6021 | ||||||||||||||||||
| Official Date: | 1 May 2015 | ||||||||||||||||||
| Dates: |
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| Volume: | 467 | ||||||||||||||||||
| Number: | 3 | ||||||||||||||||||
| Page Range: | pp. 529-536 | ||||||||||||||||||
| DOI: | 10.1042/BJ20150039 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| Date of first compliant deposit: | 10 July 2019 | ||||||||||||||||||
| Date of first compliant Open Access: | 17 July 2019 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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