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Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

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Richards, Mark W., O'Regan, Laura, Roth, Daniel, Montgomery, Jessica M., Straube, Anne, Fry, Andrew M. and Bayliss, Richard (2015) Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain. Biochemical Journal, 467 (3). pp. 529-536. doi:10.1042/BJ20150039

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Official URL: http://doi.org/10.1042/BJ20150039

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Abstract

We present crystal structures of a trimeric coiled-coil domain found in echinoderm microtubule (MT)-associated protein (EMAP)-like (EML) proteins. This trimerization domain (TD) mediates self-association and interactions between a subset of EML proteins. MT-association of EML proteins requires the TD and an adjacent basic region.

Item Type: Journal Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Crystals -- Structure, Microtubules, Tubulins
Journal or Publication Title: Biochemical Journal
Publisher: Portland Press
ISSN: 0264-6021
Official Date: 1 May 2015
Dates:
DateEvent
1 May 2015Published
5 March 2015Accepted
Date of first compliant deposit: 10 July 2019
Volume: 467
Number: 3
Page Range: pp. 529-536
DOI: 10.1042/BJ20150039
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
University Research Fellowship [RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
C24461/A12772Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
UNSPECIFIEDMarie Curie Cancer Carehttp://dx.doi.org/10.13039/501100000654
UNSPECIFIEDLister Institute of Preventive Medicinehttp://dx.doi.org/10.13039/501100001255
UNSPECIFIEDWorldwide Cancer Researchhttp://dx.doi.org/10.13039/100011713
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