The Library
Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain
Tools
Tools
Tools
Richards, Mark W., O'Regan, Laura, Roth, Daniel, Montgomery, Jessica M., Straube, Anne, Fry, Andrew M. and Bayliss, Richard (2015) Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain. Biochemical Journal, 467 (3). pp. 529-536. doi:10.1042/BJ20150039
|
PDF
WRAP-microtubule-EML-proteins-oncoprotein-terminal-domain-Straube-2015.pdf - Accepted Version - Requires a PDF viewer. Download (1646Kb) | Preview |
Official URL: http://doi.org/10.1042/BJ20150039
Abstract
We present crystal structures of a trimeric coiled-coil domain found in echinoderm microtubule (MT)-associated protein (EMAP)-like (EML) proteins. This trimerization domain (TD) mediates self-association and interactions between a subset of EML proteins. MT-association of EML proteins requires the TD and an adjacent basic region.
| Item Type: | Journal Article | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
||||||||||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Crystals -- Structure, Microtubules, Tubulins | ||||||||||||||||||
| Journal or Publication Title: | Biochemical Journal | ||||||||||||||||||
| Publisher: | Portland Press | ||||||||||||||||||
| ISSN: | 0264-6021 | ||||||||||||||||||
| Official Date: | 1 May 2015 | ||||||||||||||||||
| Dates: |
|
||||||||||||||||||
| Volume: | 467 | ||||||||||||||||||
| Number: | 3 | ||||||||||||||||||
| Page Range: | pp. 529-536 | ||||||||||||||||||
| DOI: | 10.1042/BJ20150039 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
||||||||||||||||||
| Open Access Version: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
