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Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful?
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Arduini, Arduino, Zammit, Victor A. and Bonomini, Mario (2020) Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful? Gut, 69 (2). pp. 400-401. doi:10.1136/gutjnl-2018-318000 ISSN 0017-5749.
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Official URL: http://dx.doi.org/10.1136/gutjnl-2018-318000
Abstract
We read with great interest the paper by Wu et al 1 reporting on the development of a carnitine challenge test to facilitate the identification of trimethylamine N-oxide (TMAO)-producer phenotype and host-diet-gut dysbiosis. Such a test assumes that, according to a partial reading of the literature, TMAO plays a key role in cardiovascular disease (CVD). Accordingly, the authors assert the implied importance of the potential for adverse CVD-inducing actions of compounds generating TMAO subsequent to the action of gut microbiota on dietary carnitine. However, a more objective reading of the literature shows that the biomedical community is still debating the potential involvement of TMAO in inducing …
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| Journal or Publication Title: | Gut | ||||||||
| Publisher: | BMJ Group | ||||||||
| ISSN: | 0017-5749 | ||||||||
| Official Date: | 7 January 2020 | ||||||||
| Dates: |
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| Volume: | 69 | ||||||||
| Number: | 2 | ||||||||
| Page Range: | pp. 400-401 | ||||||||
| DOI: | 10.1136/gutjnl-2018-318000 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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