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Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful?

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Arduini, Arduino, Zammit, Victor A. and Bonomini, Mario (2020) Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful? Gut, 69 (2). pp. 400-401. doi:10.1136/gutjnl-2018-318000

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Official URL: http://dx.doi.org/10.1136/gutjnl-2018-318000

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Abstract

We read with great interest the paper by Wu et al 1 reporting on the development of a carnitine challenge test to facilitate the identification of trimethylamine N-oxide (TMAO)-producer phenotype and host-diet-gut dysbiosis. Such a test assumes that, according to a partial reading of the literature, TMAO plays a key role in cardiovascular disease (CVD). Accordingly, the authors assert the implied importance of the potential for adverse CVD-inducing actions of compounds generating TMAO subsequent to the action of gut microbiota on dietary carnitine. However, a more objective reading of the literature shows that the biomedical community is still debating the potential involvement of TMAO in inducing …

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Gut
Publisher: BMJ Group
ISSN: 0017-5749
Official Date: 7 January 2020
Dates:
DateEvent
7 January 2020Published
11 January 2019Available
12 December 2018Accepted
Volume: 69
Number: 2
Page Range: pp. 400-401
DOI: 10.1136/gutjnl-2018-318000
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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