Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Molecular development of the pancreatic β-cell : implications for cell replacement therapy

Tools
- Tools
+ Tools

Ball, S. G. and Barber, Thomas M. (2003) Molecular development of the pancreatic β-cell : implications for cell replacement therapy. Trends in Endocrinology and Metabolism, 14 (8). pp. 349-355. doi:10.1016/S1043-2760(03)00105-X

Research output not available from this repository, contact author.
Official URL: https://doi.org/10.1016/S1043-2760(03)00105-X

Request Changes to record.

Abstract

Conventional insulin therapy is an imperfect treatment for diabetes mellitus, often failing to match insulin with prevailing blood glucose concentration. Accordingly, there is a drive for approaches such as β-cell replacement therapy, which is a permanent replacement for the lack of endogenous insulin production. The lack of cadaveric islets for transplantation determines that researchers must explore alternative sources of graft material. Cell engineering of non-β cells and selective expansion of stem cells are key potential sources. The past decade has witnessed an increase in our understanding of the molecular basis of pancreas and β-cell development. Our understanding of the molecular blueprint of how a β cell is made and maintained is crucial to realizing the potential of cell engineering and stem cell technologies in this area. This review outlines progress in this exciting field and highlights the key role of development in guiding our appraisal of these new technologies.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Trends in Endocrinology and Metabolism
Publisher: Elsevier
ISSN: 1043-2760
Official Date: 1 October 2003
Dates:
DateEvent
1 October 2003Published
1 March 2003Accepted
Volume: 14
Number: 8
Page Range: pp. 349-355
DOI: 10.1016/S1043-2760(03)00105-X
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us