The Library
Molecular development of the pancreatic β-cell : implications for cell replacement therapy
Tools
Tools
Tools
Ball, S. G. and Barber, Thomas M. (2003) Molecular development of the pancreatic β-cell : implications for cell replacement therapy. Trends in Endocrinology and Metabolism, 14 (8). pp. 349-355. doi:10.1016/S1043-2760(03)00105-X
Research output not available from this repository, contact author.
Official URL: https://doi.org/10.1016/S1043-2760(03)00105-X
Abstract
Conventional insulin therapy is an imperfect treatment for diabetes mellitus, often failing to match insulin with prevailing blood glucose concentration. Accordingly, there is a drive for approaches such as β-cell replacement therapy, which is a permanent replacement for the lack of endogenous insulin production. The lack of cadaveric islets for transplantation determines that researchers must explore alternative sources of graft material. Cell engineering of non-β cells and selective expansion of stem cells are key potential sources. The past decade has witnessed an increase in our understanding of the molecular basis of pancreas and β-cell development. Our understanding of the molecular blueprint of how a β cell is made and maintained is crucial to realizing the potential of cell engineering and stem cell technologies in this area. This review outlines progress in this exciting field and highlights the key role of development in guiding our appraisal of these new technologies.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
||||||
| Journal or Publication Title: | Trends in Endocrinology and Metabolism | ||||||
| Publisher: | Elsevier | ||||||
| ISSN: | 1043-2760 | ||||||
| Official Date: | 1 October 2003 | ||||||
| Dates: |
|
||||||
| Volume: | 14 | ||||||
| Number: | 8 | ||||||
| Page Range: | pp. 349-355 | ||||||
| DOI: | 10.1016/S1043-2760(03)00105-X | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
