Barber, Thomas M., McCarthy, M. I., Wass, J. A. H. and Franks , S. (2006) Obesity and polycystic ovary syndrome. Clinical Endocrinology, 65 (2). pp. 137-145. doi:10.1111/j.1365-2265.2006.02587.x

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Abstract

The aetiology of Polycystic Ovary Syndrome (PCOS) is complex and multifactorial. There is much evidence, however, to suggest that adipose tissue plays an important role in the development and maintenance of PCOS pathology. There is a close correlation between adiposity and symptom severity in women with PCOS, and even modest reductions in weight generally translate into significant improvements in menstrual regularity, fertility and hyperandrogenic features. This review article considers the various mechanisms that might underlie this link between excess adiposity and PCOS – including the effects of differential insulin sensitivity, abnormal steroid hormone metabolism and adipocytokine secretion. Greater attention to the therapeutic options available to reduce the impact of excess adiposity on ovarian and metabolic function is essential to the management of PCOS.

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Clinical Endocrinology
Publisher:	Wiley-Blackwell Publishing Ltd
ISSN:	0300-0664
Official Date:	August 2006
Dates:	Date Event August 2006 Published 6 July 2006 Available 1 June 2006 Accepted
Volume:	65
Number:	2
Page Range:	pp. 137-145
DOI:	10.1111/j.1365-2265.2006.02587.x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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