UNSPECIFIED (2001) Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin. CLINICAL ENDOCRINOLOGY, 54 (4). pp. 533-539. ISSN 0300-0664

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Abstract

OBJECTIVE Insulin and glucocorticoids are known to increase total leptin levels. However, the effects of insulin and glucocorticoids on the components of the leptin system - free leptin (FL), hound leptin (BL) and soluble leptin receptor (SR)- have not been elucidated. The aim of this study was to determine if there is a differential effect of insulin and glucocorticoids on the leptin system. MATERIAL AND METHODS In the first of two studies (study 1), we measured free leptin (FL), bound leptin (BL), a soluble leptin receptor (SR) and insulin, by specific RIA methods, in six healthy subjects on a control day, and subsequently during a hyperinsulinaemic euglycaemic clamp study. In the second study (study 2) we measured the same parameters in six healthy subjects, before (day 1) and during administration of dexamethasone over 3 consecutive days. RESULTS In study 1, on the control day FL levels rose over the 16 h monitoring period (P = 0.051) and SR levels declined (P < 0.001), but there was no change of BL levels. Even after accounting for diurnal variation, FL levels increased even more substantially over 12 h of insulin infusion than observed on the control day (P < 0.001). In study 2, mean FL concentration doubled from day 1 to day 2 (P = 0.01) and remained elevated subsequently, in contrast to FL. BL and SR revels remained unchanged during the study. Fasting insulin levels (pmol/l) increased from day 1 to day 2, but this rise only approached significance on day 4 (P = 0.05). CONCLUSION We conclude that Insulin end dexamethasone increase free leptin levels, but do not change the concentrations of bound leptin and soluble leptin receptor. Furthermore, the dexamethasone-induced rise in leptin levels is (at least partially) Independent of the effects of glucocorticoid-induced hyperinsulinaemia.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Journal or Publication Title:	CLINICAL ENDOCRINOLOGY
Publisher:	BLACKWELL SCIENCE LTD
ISSN:	0300-0664
Date:	April 2001
Volume:	54
Number:	4
Number of Pages:	7
Page Range:	pp. 533-539
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/12190

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