UNSPECIFIED (2001) The role of corticotropin-releasing hormone receptors in placenta and fetal membranes during human pregnancy. MOLECULAR GENETICS AND METABOLISM, 72 (4). pp. 287-296. ISSN 1096-7192

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Abstract

Corticotropin-releasing hormone (CRH) is a 41 amino acid polypeptide that exerts a wide spectrum of hypothalamic and extrahypothalamic functions. Moreover, the placenta and other intrauterine tissues produce and secrete immunoreactive CRH. It has been demonstrated that placental CRH is secreted into the maternal circulation in large amounts during the third trimester of human pregnancy and may play an important role in the onset of labor. CRH exerts a number of functions within the intratuterine environment like induction of prostaglandin production and maintenance of the placental blood flow. Here we present an overview of current knowledge about the CRH receptor subtypes and their signaling properties within the fetoplacental unit. (C) 2001 Academic Press.

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics R Medicine
Journal or Publication Title:	MOLECULAR GENETICS AND METABOLISM
Publisher:	ACADEMIC PRESS INC
ISSN:	1096-7192
Official Date:	April 2001
Volume:	72
Number:	4
Number of Pages:	10
Page Range:	pp. 287-296
Identification Number:	10.1006/mgme.2001.3159
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/12253

Data sourced from Thomson Reuters' Web of Knowledge

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