An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine
UNSPECIFIED (2001) An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 28 (1). pp. 93-105. ISSN 1567-567XFull text not available from this repository.
The paper considers the structural identifiability of a parent-metabolite pharmacokinetic model for ivabradine and one of its metabolites. The model, which is linear, is consider ed initially for intravenous administration of ivabradine, and then for a combined intravenous and oral administration. In both cases, the model is shown to be unidentifiable. Simplification of the model (for both forms of administration! to that proposed by Duffull et al. (1) results in a globally structurally identifiable model. The analysis could be applied In the modeling of any drug undergoing first-pass metabolism, with plasma concentrations available from drug and metabolite.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Journal or Publication Title:||JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS|
|Publisher:||KLUWER ACADEMIC/PLENUM PUBL|
|Number of Pages:||13|
|Page Range:||pp. 93-105|
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