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Impact of autophagy and ageing on iron load and ferritin in Drosophila brain

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Jacomin, Anne-Claire, Geraki, Kalotina, Tjendana-Tjhin, Vindy, Collingwood, Joanna F. and Nezis, Ioannis P. (2019) Impact of autophagy and ageing on iron load and ferritin in Drosophila brain. Frontiers in Cell and Developmental Biology, 7 . 142 . doi:10.3389/fcell.2019.00142

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Official URL: https://doi.org/10.3389/fcell.2019.00142

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Abstract

Biometals such as iron, copper, potassium and zinc are essential regulatory elements of several biological processes. The homeostasis of biometals is often affected in age-related pathologies. Notably, impaired iron metabolism has been linked to several neurodegenerative disorders. Autophagy, an intracellular degradative process dependent on the lysosomes, is involved in the regulation of ferritin and iron levels. Impaired autophagy has been associated with normal, pathological ageing and neurodegeneration. Non-mammalian model organisms such as Drosophila have proven to be appropriate for the investigation of age-related pathologies. Here, we show that ferritin is expressed in adult Drosophila brain and that iron and holoferritin accumulate with ageing. At whole-brain level we found no direct relationship between the accumulation of holoferritin and a deficit in autophagy in aged Drosophila brain. However, synchrotron X-ray spectromicroscopy revealed an additional spectral feature in the iron-richest region of autophagy-deficient fly brains, consistent with iron-sulphur. This potentially arises from iron-sulphur clusters associated with altered mitochondrial iron homeostasis.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Autophagic vacuoles, Drosophila -- Genetics, Aging, Cells -- Aging, Metals in the body
Journal or Publication Title: Frontiers in Cell and Developmental Biology
Publisher: Frontiers Media
ISSN: 2296-634X
Official Date: 25 July 2019
Dates:
DateEvent
25 July 2019Published
10 July 2019Accepted
Volume: 7
Article Number: 142
DOI: 10.3389/fcell.2019.00142
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/L006324/1 [BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/P007856/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
SP24642 Diamond Light Sourcehttp://dx.doi.org/10.13039/100011889
SP12879Diamond Light Sourcehttp://dx.doi.org/10.13039/100011889
2P40OD010949-10A1National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
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