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Impact of autophagy and ageing on iron load and ferritin in Drosophila brain
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Jacomin, Anne-Claire, Geraki, Kalotina, Tjendana-Tjhin, Vindy, Collingwood, Joanna F. and Nezis, Ioannis P. (2019) Impact of autophagy and ageing on iron load and ferritin in Drosophila brain. Frontiers in Cell and Developmental Biology, 7 . 142 . doi:10.3389/fcell.2019.00142
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Official URL: https://doi.org/10.3389/fcell.2019.00142
Abstract
Biometals such as iron, copper, potassium and zinc are essential regulatory elements of several biological processes. The homeostasis of biometals is often affected in age-related pathologies. Notably, impaired iron metabolism has been linked to several neurodegenerative disorders. Autophagy, an intracellular degradative process dependent on the lysosomes, is involved in the regulation of ferritin and iron levels. Impaired autophagy has been associated with normal, pathological ageing and neurodegeneration. Non-mammalian model organisms such as Drosophila have proven to be appropriate for the investigation of age-related pathologies. Here, we show that ferritin is expressed in adult Drosophila brain and that iron and holoferritin accumulate with ageing. At whole-brain level we found no direct relationship between the accumulation of holoferritin and a deficit in autophagy in aged Drosophila brain. However, synchrotron X-ray spectromicroscopy revealed an additional spectral feature in the iron-richest region of autophagy-deficient fly brains, consistent with iron-sulphur. This potentially arises from iron-sulphur clusters associated with altered mitochondrial iron homeostasis.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Autophagic vacuoles, Drosophila -- Genetics, Aging, Cells -- Aging, Metals in the body | ||||||||||||||||||
| Journal or Publication Title: | Frontiers in Cell and Developmental Biology | ||||||||||||||||||
| Publisher: | Frontiers Media | ||||||||||||||||||
| ISSN: | 2296-634X | ||||||||||||||||||
| Official Date: | 25 July 2019 | ||||||||||||||||||
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| Volume: | 7 | ||||||||||||||||||
| Article Number: | 142 | ||||||||||||||||||
| DOI: | 10.3389/fcell.2019.00142 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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