Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts

Tools
- Tools
+ Tools

Li, Shen, Oh, Byoung Chol, Chu, Chengyan, Arnold, Antje, Jablonska, Anna, Furtmüller, Georg J., Qin, Hua-Min, Boltze, Johannes, Magnus, Tim, Ludewig, Peter, Janowski, Mirosław, Brandacher, Gerald and Walczak, Piotr (2019) Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts. Brain, 142 (11). pp. 3456-3472. doi:10.1093/brain/awz275

[img]
Preview
PDF
WRAP-induction-immunological-tolerance-myelinogenic-glial-restricted-Boltze-2019.pdf - Accepted Version - Requires a PDF viewer.

Download (7Mb) | Preview
Official URL: https://doi.org/10.1093/brain/awz275

Request Changes to record.

Abstract

The immunological barrier currently precludes the clinical utilization of allogeneic stem cells. Although glial-restricted progenitors have become attractive candidates to treat a wide variety of neurological diseases, their survival in immunocompetent recipients is limited. In this study, we adopted a short-term, systemically applicable co-stimulation blockade-based strategy using CTLA4-Ig and anti-CD154 antibodies to modulate T-cell activation in the context of allogeneic glial-restricted progenitor transplantation. We found that co-stimulation blockade successfully prevented rejection of allogeneic glial-restricted progenitors from immunocompetent mouse brains. The long-term engrafted glial-restricted progenitors myelinated dysmyelinated adult mouse brains within one month. Furthermore, we identified a set of plasma miRNAs whose levels specifically correlated to the dynamic changes of immunoreactivity and as such could serve as biomarkers for graft rejection or tolerance. We put forward a successful strategy to induce alloantigen-specific hyporesponsiveness towards stem cells in the CNS, which will foster effective therapeutic application of allogeneic stem cells.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Myelination, Stem cells, Immunological tolerance, Homografts
Journal or Publication Title: Brain
Publisher: Oxford University Press
ISSN: 0006-8950
Official Date: November 2019
Dates:
DateEvent
November 2019Published
16 September 2019Available
11 July 2019Accepted
Date of first compliant deposit: 23 July 2019
Volume: 142
Number: 11
Page Range: pp. 3456-3472
DOI: 10.1093/brain/awz275
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: This is a pre-copyedited, author-produced version of an article accepted for publication in Brain following peer review. The version of record, Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts, Brain, Volume 142, Issue 11, November 2019, Pages 3456–3472 is available online at: https://doi.org/10.1093/brain/awz275
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
R01NS091110National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
R01NS091100National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
R01NS102675National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
2017-MSCRFD-3942National Institutes of Healthhttp://dx.doi.org/10.13039/100000002

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us