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Capacity planning for networks of stem-cell donation centres under uncertainty
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Gökalp, E., Gulpinar, Nalan and Doan, Xuan Vinh (2020) Capacity planning for networks of stem-cell donation centres under uncertainty. Production and Operations Management, 29 (2). pp. 281-297. doi:10.1111/poms.13090
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WRAP-Capacity-networks-stem-cell-donation-uncertainty-Gulpinar-2019.pdf - Accepted Version - Requires a PDF viewer. Download (884Kb) | Preview |
Official URL: https://doi.org/10.1111/poms.13090
Abstract
Stem‐cell transplantation is the last chance for patients of various blood‐related diseases. Stem‐cell donation centres admit patients in need of a stem‐cell transplant and search for a perfect match between the patients and donors. The search process is time‐consuming and requires expensive advanced equipments, in particular for DNA typing. In this paper, we are concerned with a capacity planning problem in a network of stem‐cell donation centres. The underlying optimization model integrates the operations for a donor search and aims to maximize the number of transplantations. A scenario‐based stochastic programming approach is introduced to investigate the effect of the demand and service time variabilities into the capacity planning problem. We consider the maximum possible waiting time during the search process to obtain robust solutions against uncertainties. For this purpose, we approximate the maximum waiting time in the advanced blood testing with a robust queuing approach. The computational experiments are designed to illustrate the performance of the capacity planning model.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology | ||||||||
| Divisions: | Faculty of Social Sciences > Warwick Business School | ||||||||
| Library of Congress Subject Headings (LCSH): | Stem cells -- Transplantation, Health services accessibility, Medical care -- Planning -- Mathematical models, Stochastic programming | ||||||||
| Journal or Publication Title: | Production and Operations Management | ||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
| ISSN: | 1059-1478 | ||||||||
| Official Date: | February 2020 | ||||||||
| Dates: |
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| Volume: | 29 | ||||||||
| Number: | 2 | ||||||||
| Page Range: | pp. 281-297 | ||||||||
| DOI: | 10.1111/poms.13090 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | This is the peer reviewed version of the following article: Gökalp, E., Gülpınar, N. and Doan, X.V. (2020), Capacity Planning for Networks of Stem‐Cell Donation Centers under Uncertainty. Prod Oper Manag, 29: 281-297. doi:10.1111/poms.13090, which has been published in final form at http://dx.doi.org/10.1111/poms.13090. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
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