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Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study

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Hopkins, Thomas, Gonçalves, Raquel, Mamani, Janet, Courtenay, Orin and Bern, Caryn (2019) Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study. International Journal of Infectious Diseases, 86 . pp. 175-177. doi:10.1016/j.ijid.2019.07.020

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Official URL: https://doi.org/10.1016/j.ijid.2019.07.020

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Abstract

Background
We screened for Trypanosoma cruzi infection amongst children in a rural community in the Bolivian Chaco, an area known for high prevalence. We also estimated the force of infection (FOI).

Methods
423 children were screened using InBios (Seattle, WA) ChagasDetectPlus (CDP) rapid test at the local school. CDP-positive specimens were further tested by indirect hemagglutination assay (IHA) and Wiener Recombinante v3.0 ELISA. A catalytic model was used to estimate FOI.

Results
Confirmed seroprevalence was 0.22, rising steeply with age. The mean age of seropositive individuals was 13 years. Rapid test specificity was calculated 91.9%, the annual incidence estimated from the FOI was 0.021.

Conclusion
This study demonstrates persistent transmission and continued high levels of T. cruzi infection in the Bolivian Chaco, and highlights the practicality of school-based screening

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science > Life Sciences (2010- )
Faculty of Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Chagas' disease , Chagas' disease -- Bolivia, Chagas' disease -- Prevention -- Bolivia, Trypanosomiasis
Journal or Publication Title: International Journal of Infectious Diseases
Publisher: Elsevier
ISSN: 1201-9712
Official Date: September 2019
Dates:
DateEvent
September 2019Published
26 July 2019Available
21 July 2019Accepted
Volume: 86
Page Range: pp. 175-177
DOI: 10.1016/j.ijid.2019.07.020
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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