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Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study
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Hopkins, Thomas, Gonçalves, Raquel, Mamani, Janet, Courtenay, Orin and Bern, Caryn (2019) Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study. International Journal of Infectious Diseases, 86 . pp. 175-177. doi:10.1016/j.ijid.2019.07.020
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WRAP-Chagas-disease-Bolivian-Chaco-Courtenay-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (340Kb) | Preview |
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WRAP-chagas-disease-Bolivian-Chaco-transmission-childhood-seroscreening-Courtenay-2019.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (716Kb) | Preview |
Official URL: https://doi.org/10.1016/j.ijid.2019.07.020
Abstract
Background
We screened for Trypanosoma cruzi infection amongst children in a rural community in the Bolivian Chaco, an area known for high prevalence. We also estimated the force of infection (FOI).
Methods
423 children were screened using InBios (Seattle, WA) ChagasDetectPlus (CDP) rapid test at the local school. CDP-positive specimens were further tested by indirect hemagglutination assay (IHA) and Wiener Recombinante v3.0 ELISA. A catalytic model was used to estimate FOI.
Results
Confirmed seroprevalence was 0.22, rising steeply with age. The mean age of seropositive individuals was 13 years. Rapid test specificity was calculated 91.9%, the annual incidence estimated from the FOI was 0.021.
Conclusion
This study demonstrates persistent transmission and continued high levels of T. cruzi infection in the Bolivian Chaco, and highlights the practicality of school-based screening
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > R Medicine (General) | ||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Chagas' disease , Chagas' disease -- Bolivia, Chagas' disease -- Prevention -- Bolivia, Trypanosomiasis | ||||||||
| Journal or Publication Title: | International Journal of Infectious Diseases | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 1201-9712 | ||||||||
| Official Date: | September 2019 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 2 August 2019 | ||||||||
| Volume: | 86 | ||||||||
| Page Range: | pp. 175-177 | ||||||||
| DOI: | 10.1016/j.ijid.2019.07.020 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
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