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Dental pulp stem cells : an attractive alternative for cell therapy in ischemic stroke
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Lan, Xiaoyan, Sun, Zhengwu, Chu, Chengyan, Boltze, Johannes and Li, Sheng (2019) Dental pulp stem cells : an attractive alternative for cell therapy in ischemic stroke. Frontiers in Neurology, 10 . 824. doi:10.3389/fneur.2019.00824
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WRAP-dental-pulp-stem-cells-attractive-alternative-cell-therapy-ischemic-stroke-Boltze-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (598Kb) | Preview |
Official URL: http://dx.doi.org/10.3389/fneur.2019.00824
Abstract
Ischemic stroke is a major cause of disability and mortality worldwide, but effective restorative treatments are very limited at present. Regenerative medicine research revealed that stem cells are promising therapeutic options. Dental pulp stem cells (DPSCs) are autologously applicable cells that origin from the neural crest and exhibit neuro-ectodermal features next to multilineage differentiation potentials. DPSCs are of increasing interest since they are relatively easy to obtain, exhibit a strong proliferation ability, and can be cryopreserved for a long time without losing their multi-directional differentiation capacity. Besides, use of DPSCs can avoid fundamental problems such as immune rejection, ethical controversy, and teratogenicity. Therefore, DPSCs provide a tempting prospect for stroke treatment.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QH Natural history R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Stem cells, Dental pulp, Cerebrovascular disease , Cerebral ischemia , Cellular therapy | |||||||||||||||
| Journal or Publication Title: | Frontiers in Neurology | |||||||||||||||
| Publisher: | Frontiers Research Foundation | |||||||||||||||
| ISSN: | 1664-2295 | |||||||||||||||
| Official Date: | 2 August 2019 | |||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 6 August 2019 | |||||||||||||||
| Volume: | 10 | |||||||||||||||
| Article Number: | 824 | |||||||||||||||
| DOI: | 10.3389/fneur.2019.00824 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||
| RIOXX Funder/Project Grant: |
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