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Dental pulp stem cells : an attractive alternative for cell therapy in ischemic stroke

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Lan, Xiaoyan, Sun, Zhengwu, Chu, Chengyan, Boltze, Johannes and Li, Sheng (2019) Dental pulp stem cells : an attractive alternative for cell therapy in ischemic stroke. Frontiers in Neurology, 10 . 824. doi:10.3389/fneur.2019.00824

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Official URL: http://dx.doi.org/10.3389/fneur.2019.00824

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Abstract

Ischemic stroke is a major cause of disability and mortality worldwide, but effective restorative treatments are very limited at present. Regenerative medicine research revealed that stem cells are promising therapeutic options. Dental pulp stem cells (DPSCs) are autologously applicable cells that origin from the neural crest and exhibit neuro-ectodermal features next to multilineage differentiation potentials. DPSCs are of increasing interest since they are relatively easy to obtain, exhibit a strong proliferation ability, and can be cryopreserved for a long time without losing their multi-directional differentiation capacity. Besides, use of DPSCs can avoid fundamental problems such as immune rejection, ethical controversy, and teratogenicity. Therefore, DPSCs provide a tempting prospect for stroke treatment.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Stem cells, Dental pulp, Cerebrovascular disease , Cerebral ischemia , Cellular therapy
Journal or Publication Title: Frontiers in Neurology
Publisher: Frontiers Research Foundation
ISSN: 1664-2295
Official Date: 2 August 2019
Dates:
DateEvent
2 August 2019Published
17 July 2019Accepted
Volume: 10
Article Number: 824
DOI: 10.3389/fneur.2019.00824
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
81300985[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
2015020549Natural Science Foundation of Liaoning Provincehttp://dx.doi.org/10.13039/501100005047
XLYC180712University of Science and Technology Liaoninghttp://dx.doi.org/10.13039/501100004767
UNSPECIFIEDDalian Shi (China)http://viaf.org/viaf/159638351

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