Jackson, Matthew D. B., Xu, Hao, Duran-Nebreda, Salva, Stamm, Petra and Bassel, George (2017) Topological analysis of multicellular complexity in the plant hypocotyl. eLife, 6 . e26023. doi:10.7554/eLife.26023

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Abstract

Multicellularity arose as a result of adaptive advantages conferred to complex cellular assemblies. The arrangement of cells within organs endows higher-order functionality through a structure-function relationship, though the organizational properties of these multicellular configurations remain poorly understood. We investigated the topological properties of complex organ architecture by digitally capturing global cellular interactions in the plant embryonic stem (hypocotyl), and analyzing these using quantitative network analysis. This revealed the presence of coherent conduits of reduced path length across epidermal atrichoblast cell files. The preferential movement of small molecules along this cell type was demonstrated using fluorescence transport assays. Both robustness and plasticity in this higher order property of atrichoblast patterning was observed across diverse genetic backgrounds, and the analysis of genetic patterning mutants identified the contribution of gene activity towards their construction. This topological analysis of multicellular structural organization reveals higher order functions for patterning and principles of complex organ construction.

Item Type:	Journal Article
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	eLife
Publisher:	eLife Sciences Publications Ltd.
ISSN:	2050-084X
Official Date:	6 July 2017
Dates:	Date Event 6 July 2017 Published
Volume:	6
Article Number:	e26023
DOI:	10.7554/eLife.26023
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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