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MorphoGraphX : a platform for quantifying morphogenesis in 4D
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(2015) MorphoGraphX : a platform for quantifying morphogenesis in 4D. eLife, 4 . doi:10.7554/eLife.05864 ISSN 2050-084X.
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Official URL: http://dx.doi.org/10.7554/eLife.05864
Abstract
Morphogenesis emerges from complex multiscale interactions between genetic and mechanical processes. To understand these processes, the evolution of cell shape, proliferation and gene expression must be quantified. This quantification is usually performed either in full 3D, which is computationally expensive and technically challenging, or on 2D planar projections, which introduces geometrical artifacts on highly curved organs. Here we present MorphoGraphX (www.MorphoGraphX.org), a software that bridges this gap by working directly with curved surface images extracted from 3D data. In addition to traditional 3D image analysis, we have developed algorithms to operate on curved surfaces, such as cell segmentation, lineage tracking and fluorescence signal quantification. The software's modular design makes it easy to include existing libraries, or to implement new algorithms. Cell geometries extracted with MorphoGraphX can be exported and used as templates for simulation models, providing a powerful platform to investigate the interactions between shape, genes and growth.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | eLife | ||||
Publisher: | eLife Sciences Publications Ltd. | ||||
ISSN: | 2050-084X | ||||
Official Date: | 2015 | ||||
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Volume: | 4 | ||||
DOI: | 10.7554/eLife.05864 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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