The Library
Molecular mechanisms of selective autophagy in Drosophila
Tools
Gohel, Raksha, Kournoutis, Athanasios, Petridi, Stavroula and Nezis, Ioannis P. (2020) Molecular mechanisms of selective autophagy in Drosophila. International Review of Cell and Molecular Biology, 354 . pp. 63-105. doi:10.1016/bs.ircmb.2019.08.003 ISSN 1937-6448.
PDF
WRAP-Molecular-mechanisms-selective-autophagy-Drosophila-Nezis-2019.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (868Kb) |
Official URL: https://doi.org/10.1016/bs.ircmb.2019.08.003
Abstract
Autophagy is a highly conserved catabolic process in which cytoplasmic material is recycled under various conditions of cellular stress, preventing cell damage and promoting survival in the event of energy or nutrient shortage, or in response to various cytotoxic insults. Autophagy is also responsible for the removal of aggregated proteins and damaged organelles, playing a vital role in the quality control of proteins and organelles. Impairment of autophagy has been linked to various diseases, including cancer and neurodegenerative disorders, making it a very interesting process for further research. Recent research highlighted that autophagy is not random and can be selective, making it even more important to understand the molecular mechanisms of selectivity at the organismal level. Drosophila has been demonstrated to be an excellent animal model for studying selective autophagy, as the autophagic machinery is highly conserved, although much is still left to be explored. In this review, an overview of autophagy and its selectivity in Drosophila will be presented.
Item Type: | Journal Article | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QH Natural history > QH426 Genetics | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
Library of Congress Subject Headings (LCSH): | Cell death, Apoptosis, Drosophila -- Genetics | |||||||||
Journal or Publication Title: | International Review of Cell and Molecular Biology | |||||||||
Publisher: | Elsevier Inc. | |||||||||
ISSN: | 1937-6448 | |||||||||
Official Date: | 2020 | |||||||||
Dates: |
|
|||||||||
Volume: | 354 | |||||||||
Page Range: | pp. 63-105 | |||||||||
DOI: | 10.1016/bs.ircmb.2019.08.003 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Date of first compliant deposit: | 27 August 2019 | |||||||||
RIOXX Funder/Project Grant: |
|
|||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |