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Medicine in the fourth dimension
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Cederroth, Christopher R., Albrecht, Urs, Bass, Joseph, Brown, Steven A., Dyhrfjeld-Johnsen, Jonas, Gachon, Frederic, Green, Carla B., Hastings, Michael H., Helfrich-Förster, Charlotte, Hogenesch, John B., Lévi, Francis A., Loudon, Andrew, Lundkvist, Gabriella B., Meijer, Johanna H., Rosbash, Michael, Takahashi, Joseph S., Young, Michael and Canlon, Barbara (2019) Medicine in the fourth dimension. Cell Metabolism, 30 (2). pp. 238-250. doi:10.1016/j.cmet.2019.06.019 ISSN 1550-4131.
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Official URL: http://dx.doi.org/10.1016/j.cmet.2019.06.019
Abstract
The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharmacodynamics. Thus, it is now time that circadian factors become an integral part of translational research.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Cell Metabolism | ||||
| Publisher: | Elsevier | ||||
| ISSN: | 1550-4131 | ||||
| Official Date: | 6 August 2019 | ||||
| Dates: |
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| Volume: | 30 | ||||
| Number: | 2 | ||||
| Page Range: | pp. 238-250 | ||||
| DOI: | 10.1016/j.cmet.2019.06.019 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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