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Infarct evolution in a large animal model of middle cerebral artery occlusion
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Shazeeb, Mohammed Salman , King, Robert M., Brooks, Olivia W., Puri, Ajit S., Henninger, Nils, Boltze, Johannes and Gounis, Matthew J. (2020) Infarct evolution in a large animal model of middle cerebral artery occlusion. Translational Stroke Research, 11 . pp. 468-480. doi:10.1007/s12975-019-00732-9
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WRAP-infarct-evolution-large-animal-model-middle-cerebral-artery-occlusion-Boltze-2019.pdf - Accepted Version - Requires a PDF viewer. Download (2773Kb) | Preview |
Official URL: https://doi.org/10.1007/s12975-019-00732-9
Abstract
Mechanical thrombectomy for the treatment of ischemic stroke shows high rates of recanalization; however, some patients still have a poor clinical outcome. A proposed reason for this relates to the fact that the ischemic infarct growth differs significantly between patients. While some patients demonstrate rapid evolution of their infarct core (fast evolvers), others have substantial potentially salvageable penumbral tissue even hours after initial vessel occlusion (slow evolvers). We show that the dog middle cerebral artery occlusion model recapitulates this key aspect of human stroke rendering it a highly desirable model to develop novel multimodal treatments to improve clinical outcomes. Moreover, this model is well suited to develop novel image analysis techniques that allow for improved lesion evolution prediction; we provide proof-of-concept that MRI perfusion-based time-to-peak maps can be utilized to predict the rate of infarct growth as validated by apparent diffusion coefficient-derived lesion maps allowing reliable classification of dogs into fast versus slow evolvers enabling more robust study design for interventional research.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine R Medicine > RD Surgery |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Cerebrovascular disease -- Surgery, Cerebral ischemia, Blood-vessels -- Endoscopic surgery -- Technique | ||||||||
| Journal or Publication Title: | Translational Stroke Research | ||||||||
| Publisher: | Springer | ||||||||
| ISSN: | 1868-4483 | ||||||||
| Official Date: | June 2020 | ||||||||
| Dates: |
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| Volume: | 11 | ||||||||
| Page Range: | pp. 468-480 | ||||||||
| DOI: | 10.1007/s12975-019-00732-9 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Publisher Statement: | This is a post-peer-review, pre-copyedit version of an article published in Translational Stroke Research. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12975-019-00732-9 | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| RIOXX Funder/Project Grant: |
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