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Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKy to control inflammation
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Jacomin, Anne-Claire and Nezis, Ioannis P. (2020) Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKy to control inflammation. Molecular & Cellular Oncology, 7 (1). 1682309 . doi:10.1080/23723556.2019.1682309 ISSN 2372-3556.
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Official URL: https://doi.org/10.1080/23723556.2019.1682309
Abstract
Implication of autophagy in the downregulation of immune signalling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila Kenny/IKK with the autophagic machinery is required for the degradation of the IKK complex. This regulatory mechanism is essential for the downregulation of the IMD immune pathway in response to commensal microbiota to prevent inflammation
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
Library of Congress Subject Headings (LCSH): | Autophagic vacuoles, Drosophila, Molecular biology -- Research | |||||||||
Journal or Publication Title: | Molecular & Cellular Oncology | |||||||||
Publisher: | Taylor & Francis Inc. | |||||||||
ISSN: | 2372-3556 | |||||||||
Official Date: | 2020 | |||||||||
Dates: |
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Volume: | 7 | |||||||||
Number: | 1 | |||||||||
Article Number: | 1682309 | |||||||||
DOI: | 10.1080/23723556.2019.1682309 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 27 August 2019 | |||||||||
Date of first compliant Open Access: | 6 October 2020 | |||||||||
RIOXX Funder/Project Grant: |
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