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Targeting intracellular, multi-drug resistant Staphylococcus aureus with guanidinium polymers by elucidating the structure-activity relationship
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Kuroki, Agnès, Kengmo Tchoupa, Arnaud, Hartlieb, Matthias, Peltier, Raoul, Locock, Katherine E. S., Unnikrishnan, Meera and Perrier, Sébastien (2019) Targeting intracellular, multi-drug resistant Staphylococcus aureus with guanidinium polymers by elucidating the structure-activity relationship. Biomaterials, 217 . 119249. doi:10.1016/j.biomaterials.2019.119249 ISSN 0142-9612.
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WRAP-targeting-intracellular-multi-drug-resistant-Staphylococcus-aureus-guanidinium-polymers-elucidating-structure-activity-relationship-Perrier-2019.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (2072Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.biomaterials.2019.1192...
Abstract
Intracellular persistence of bacteria represents a clinical challenge as bacteria can thrive in an environment protected from antibiotics and immune responses. Novel targeting strategies are critical in tackling antibiotic resistant infections. Synthetic antimicrobial peptides (SAMPs) are interesting candidates as they exhibit a very high antimicrobial activity. We first compared the activity of a library of ammonium and guanidinium polymers with different sequences (statistical, tetrablock and diblock) synthesized by RAFT polymerization against methicillin-resistant S. aureus (MRSA) and methicillin-sensitive strains (MSSA). As the guanidinium SAMPs were the most potent, they were used to treat intracellular S. aureus in keratinocytes. The diblock structure was the most active, reducing the amount of intracellular MSSA and MRSA by two-fold. We present here a potential treatment for intracellular, multi-drug resistant bacteria, using a simple and scalable strategy.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Anti-infective agents, Bacterial diseases, Block copolymers, Addition polymerization | ||||||||||||||||||
Journal or Publication Title: | Biomaterials | ||||||||||||||||||
Publisher: | Elsevier Science BV | ||||||||||||||||||
ISSN: | 0142-9612 | ||||||||||||||||||
Official Date: | October 2019 | ||||||||||||||||||
Dates: |
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Volume: | 217 | ||||||||||||||||||
Article Number: | 119249 | ||||||||||||||||||
DOI: | 10.1016/j.biomaterials.2019.119249 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
Date of first compliant deposit: | 29 August 2019 | ||||||||||||||||||
Date of first compliant Open Access: | 18 June 2020 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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