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Mechanism of action of nucleoside antibacterial natural product antibiotics
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Bugg, Tim and Kerr, Rachel V. (2019) Mechanism of action of nucleoside antibacterial natural product antibiotics. Journal of Antibiotics, 72 . pp. 865-876. doi:10.1038/s41429-019-0227-3 ISSN 0021-8820.
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Official URL: https://doi.org/10.1038/s41429-019-0227-3
Abstract
This article reviews the structures and biological activities of several classes of uridine-containing nucleoside antibiotics (tunicamycins, mureidomycins/pacidamycins/sansanmycins, liposidomycins/caprazamycins, muraymycins, capuramycins) that target translocase MraY on the peptidoglycan biosynthetic pathway. In particular, recent advances in structure-function studies, and recent X-ray crystal structures of translocase MraY complexed with muraymycin D2 and tunicamycin are described. The inhibition of other phospho-nucleotide transferase enzymes related to MraY by nucleoside antibiotics and analogues is also reviewed.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
| Library of Congress Subject Headings (LCSH): | Nucleosides, Antiviral nucleosides -- Synthesis | ||||||||
| Journal or Publication Title: | Journal of Antibiotics | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 0021-8820 | ||||||||
| Official Date: | December 2019 | ||||||||
| Dates: |
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| Volume: | 72 | ||||||||
| Page Range: | pp. 865-876 | ||||||||
| DOI: | 10.1038/s41429-019-0227-3 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 29 August 2019 | ||||||||
| Date of first compliant Open Access: | 1 March 2020 | ||||||||
| RIOXX Funder/Project Grant: |
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