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Branching dendrites with resonant membrane: a “sum-over-trips” approach
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Coombes, Stephen, Timofeeva, Yulia, Svensson, Carl-Magnus, Lord, G. J. (Gabriel J.), Josić, Krešimir, Cox, S. J. and Colbert, Costa M. (2007) Branching dendrites with resonant membrane: a “sum-over-trips” approach. Biological Cybernetics, Vol.97 (No.2). pp. 137-149. doi:10.1007/s00422-007-0161-5 ISSN 0340-1200.
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Official URL: http://dx.doi.org/10.1007/s00422-007-0161-5
Abstract
Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dendrites. Another important contribution to the response characteristics of a single neuron comes from the intrinsic resonant properties of dendritic membrane. In this paper we combine the effects of dendritic branching and resonant membrane dynamics by generalising the “sum-over-trips” approach (Abbott et al. in Biol Cybernetics 66, 49–60 1991). To illustrate how this formalism can shed light on the role of architecture and resonances in determining neuronal output we consider dual recording and reconstruction data from a rat CA1 hippocampal pyramidal cell. Specifically we explore the way in which an Ih current contributes to a voltage overshoot at the soma.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||
Library of Congress Subject Headings (LCSH): | Dendrites -- Research, Membranes (Biology) -- Electric properties, Synapses -- Research, Neural transmission, Neural circuitry | ||||
Journal or Publication Title: | Biological Cybernetics | ||||
Publisher: | Springer | ||||
ISSN: | 0340-1200 | ||||
Official Date: | August 2007 | ||||
Dates: |
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Volume: | Vol.97 | ||||
Number: | No.2 | ||||
Page Range: | pp. 137-149 | ||||
DOI: | 10.1007/s00422-007-0161-5 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), National Institutes of Health (U.S.) (NIH), Great Britain. Dept. of Trade and Industry (DTI) | ||||
Grant number: | GR/S60914/01 (EPSRC), GR/R76219 (EPSRC), R01 AG027577 (NIH) |
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