Coombes, Stephen, Timofeeva, Yulia, Svensson, Carl-Magnus, Lord, G. J. (Gabriel J.), Josić, Krešimir, Cox, S. J. and Colbert, Costa M.. (2007) Branching dendrites with resonant membrane: a “sum-over-trips” approach. Biological Cybernetics, Vol.97 (No.2). pp. 137-149. ISSN 0340-1200

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Abstract

Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dendrites. Another important contribution to the response characteristics of a single neuron comes from the intrinsic resonant properties of dendritic membrane. In this paper we combine the effects of dendritic branching and resonant membrane dynamics by generalising the “sum-over-trips” approach (Abbott et al. in Biol Cybernetics 66, 49–60 1991). To illustrate how this formalism can shed light on the role of architecture and resonances in determining neuronal output we consider dual recording and reconstruction data from a rat CA1 hippocampal pyramidal cell. Specifically we explore the way in which an Ih current contributes to a voltage overshoot at the soma.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH):	Dendrites -- Research, Membranes (Biology) -- Electric properties, Synapses -- Research, Neural transmission, Neural circuitry
Journal or Publication Title:	Biological Cybernetics
Publisher:	Springer
ISSN:	0340-1200
Date:	August 2007
Volume:	Vol.97
Number:	No.2
Page Range:	pp. 137-149
Identification Number:	10.1007/s00422-007-0161-5
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), National Institutes of Health (U.S.) (NIH), Great Britain. Dept. of Trade and Industry (DTI)
Grant number:	GR/S60914/01 (EPSRC), GR/R76219 (EPSRC), R01 AG027577 (NIH)
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URI:	http://wrap.warwick.ac.uk/id/eprint/1250

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