MIP-1 alpha is produced but it does not control pulmonary inflammation in response to respiratory syncytial virus infection in mice
UNSPECIFIED. (2000) MIP-1 alpha is produced but it does not control pulmonary inflammation in response to respiratory syncytial virus infection in mice. CELLULAR IMMUNOLOGY, 206 (1). pp. 1-6. ISSN 0008-8749Full text not available from this repository.
The intent of this study was to compare the cellular and biochemical inflammatory responses of mice infected with the paramyxovirus pathogens respiratory syncytial virus (RSV) and pneumonia virus of mice (PVM), Although RSV is not a natural pathogen of mice, it has been used extensively in mouse models of the human disease, as a limited respiratory infection can be established via intranasal inoculation of virus at high titer. In earlier work, we found that acute infection with the natural rodent pathogen, PVM, elicited a rapid and sustained pulmonary inflammatory response (peak, 1.7 x 10(6) leukocytes/ml BAL fluid) that was dependent on both local production of MIP-1 alpha and signaling via its receptor, CCR1. We find here that MIP-1 alpha is also produced in response to RSV, although relatively few leukocytes (<200 ml BAL fluid) are recruited to the lungs in response. Further experiments with CCR1-deficient mice confirm the finding that although MIP-1<alpha> is produced in response to RSV infection, leukocytes do not respond via this pathway. Among the explanations for these findings, we propose that there are other, as yet to be identified proinflammatory mediators elicited in response to PVM (but not in response to RSV) that serve to prime the leukocytes in vivo, thus enabling them to respond to MIP-1 alpha signaling via CCR1, Furthermore, the differences in disease pathogenesis seen in response to each of these pneumovirus infections in mice raise questions regarding the extent to which primary RSV infection in mice can be used as a model of primary RSV infection in humans. (C) 2000 Academic Press.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology > QR180 Immunology
|Journal or Publication Title:||CELLULAR IMMUNOLOGY|
|Publisher:||ACADEMIC PRESS INC|
|Date:||25 November 2000|
|Number of Pages:||6|
|Page Range:||pp. 1-6|
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