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Obesity and polycystic ovary syndrome : implications for pathogenesis and novel management strategies
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Barber, Thomas M., Hanson, Petra, Weickert, Martin O. and Franks, Stephen (2019) Obesity and polycystic ovary syndrome : implications for pathogenesis and novel management strategies. Clinical Medicine Insights: Reproductive Health, 13 . doi:10.1177/1179558119874042
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WRAP-Obesity-polycystic-ovary-pathogenesis-novel-Barber-2019.pdf - Accepted Version - Requires a PDF viewer. Download (720Kb) | Preview |
Official URL: https://doi.org/10.1177/1179558119874042
Abstract
Polycystic ovary syndrome (PCOS) is a common female condition typified by reproductive, hyperandrogenic, and metabolic features. Polycystic ovary syndrome is a genetic condition, exacerbated by obesity. There is a close link between obesity and PCOS based on epidemiological data, and more recently corroborated through genetic studies. There are many mechanisms mediating the effects of weight-gain and obesity on the development of PCOS. The metabolic effects of insulin resistance and steroidogenic and reproductive effects of hyperinsulinaemia are important mechanisms. Adipokine production by subcutaneous and visceral fat appears to play a part in metabolic function. However, given the complexity of PCOS pathogenesis, it is important also to consider possible effects of PCOS on further weight-gain, or at least on hampering attempts at weight-loss and maintenance through lifestyle changes. Possible mediators of these effects include changes in energy expenditure, mental ill health, or physical inactivity. In this brief review, we discuss the main mechanisms that underlie the association between obesity and PCOS, from divergent perspectives of weight-gain contributing to development of PCOS and vice versa. We also consider novel management options for women with obesity and PCOS.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Polycystic ovary syndrome , Polycystic ovary syndrome -- Treatment, Polycystic ovary syndrome -- Pathophysiology, Obesity , Obesity in women | ||||||||
| Journal or Publication Title: | Clinical Medicine Insights: Reproductive Health | ||||||||
| Publisher: | Sage Publications Ltd. | ||||||||
| ISSN: | 1178-6299 | ||||||||
| Official Date: | 1 January 2019 | ||||||||
| Dates: |
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| Volume: | 13 | ||||||||
| DOI: | 10.1177/1179558119874042 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Publisher Statement: | Posted ahead of print. Barber, Thomas M., Hanson, Petra, Weickert, Martin O. and Franks, Stephen (2019) Obesity and polycystic ovary syndrome : implications for pathogenesis and novel management strategies. Clinical Medicine Insights: Reproductive Health . (In Press) Copyright © 2019 (The Author). Reprinted by permission of SAGE Publications. DOI: [DOI] | ||||||||
| Access rights to Published version: | Open Access | ||||||||
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