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Geant4 simulations for microbeam radiation therapy (MRT) dosimetry
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Spiga, Jenny, Siegbahn, Eric A., Brauer-Krisch, Elke, Randaccio, Paolo and Bravin, Alberto (2008) Geant4 simulations for microbeam radiation therapy (MRT) dosimetry. In: IEEE Nuclear Science Symposium Conference, Honolulu, HI, USA, 26 Oct-3 Nov 2007. Published in: 2007 IEEE Nuclear Science Symposium Conference Record pp. 2571-2575. ISSN 1082-3654. doi:10.1109/NSSMIC.2007.4436675
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Official URL: http://dx.doi.org/10.1109/NSSMIC.2007.4436675
Abstract
Radiation therapy is one of the techniques most commonly used in the treatment of various types of tumors. The microbeam radiation therapy (MRT) is a very promising variant, which exploits the property that tissues can tolerate high doses of radiation in small volumes. The effectiveness of MRT is well represented by the peak-to-valley dose ratios (PVDRs), which are one of the crucial parameters associated with the outcome of the treatment. In this study, we investigate on the factors that influence PVDRs, such as different beam energies and geometries. MRT experiments typically employ rectangular (planar) microbeams of different sizes, but, for convenience of analysis, preliminary computations have been performed also using arrays of cylindrical microbeams. This work shows that the shape of the impinging irradiation field largely influences the dose distribution. It highlights that a bundle of larger microbeams, with a small separation, produces more scattered radiation and therefore lower PVDRs. The study of how dose distributions vary with different setups and irradiation parameters is an essential step in enhancing the comparability of experimental data and simulation results.
| Item Type: | Conference Item (Paper) | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||
| Journal or Publication Title: | 2007 IEEE Nuclear Science Symposium Conference Record | ||||||
| Publisher: | IEEE | ||||||
| ISSN: | 1082-3654 | ||||||
| Book Title: | 2007 IEEE Nuclear Science Symposium Conference Record | ||||||
| Official Date: | 22 January 2008 | ||||||
| Dates: |
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| Page Range: | pp. 2571-2575 | ||||||
| DOI: | 10.1109/NSSMIC.2007.4436675 | ||||||
| Status: | Not Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Conference Paper Type: | Paper | ||||||
| Title of Event: | IEEE Nuclear Science Symposium Conference | ||||||
| Type of Event: | Conference | ||||||
| Location of Event: | Honolulu, HI, USA | ||||||
| Date(s) of Event: | 26 Oct-3 Nov 2007 |
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