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In vivo terahertz imaging to evaluate scar treatment strategies : silicone gel sheeting

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Wang, Jiarui, Sun, Qiushuo, Stantchev, Rayko I., Chiu, Tor-Wo, Ahuja, Anil T. and Pickwell-MacPherson, Emma (2019) In vivo terahertz imaging to evaluate scar treatment strategies : silicone gel sheeting. Biomedical Optics Express, 10 (7). pp. 3584-3590. doi:10.1364/BOE.10.003584 ISSN 2156-7085.

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Official URL: http://dx.doi.org/10.1364/BOE.10.003584

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Abstract

Silicone gel sheeting (SGS) is widely used for scar treatment; however, studies showing its interaction with skin and efficacy of scar treatment are still lacking. THz light is non-ionizing and highly sensitive to changes in water content and thus skin hydration. In this work, we use in-vivo THz imaging to monitor how SGS affects the THz response of human skin during occlusion, and the associated THz reflectivity and refractive index changes are presented. We find that SGS effectively hydrates the skin beneath it, with minimal lateral effects beyond the sheeting. Our work demonstrates that THz imaging is able to detect the subtle hydration changes on the surface of human skin caused by SGS, and it has the potential to be used to evaluate different scar treatment strategies.

Item Type: Journal Article
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RD Surgery
Divisions: Faculty of Science, Engineering and Medicine > Science > Physics
Library of Congress Subject Headings (LCSH): Terahertz spectroscopy, Diagnostic imaging, Silicones in surgery , Scars -- Treatment
Journal or Publication Title: Biomedical Optics Express
Publisher: Optical Society of America
ISSN: 2156-7085
Official Date: 1 July 2019
Dates:
DateEvent
1 July 2019Published
6 June 2019Accepted
Volume: 10
Number: 7
Page Range: pp. 3584-3590
DOI: 10.1364/BOE.10.003584
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 19 September 2019
Date of first compliant Open Access: 19 September 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
14206717Research Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920
14201415Research Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920
ITS/371/16Innovation and Technology Fundhttp://dx.doi.org/10.13039/501100010428
PhD Fellowship AwardResearch Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920
Wolfson Merit AwardRoyal Societyhttp://dx.doi.org/10.13039/501100000288

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