UNSPECIFIED (2000) Changes in embryonic cell fate produced by expression of an endodermal transcription factor, Xsox17. MECHANISMS OF DEVELOPMENT, 99 (1-2). pp. 65-70. ISSN 0925-4773

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Abstract

Many molecules induce the ectopic expression of tissue-specific genes in Xenopus embryos. Conversely, interfering with their activity disrupts patterns of gene expression, implicating them in normal development. Does this mean that they control cell fate (i.e. position, as well as differentiation)? Xsox17 alpha and beta can induce ectopic expression of endodermal markers; inhibiting their function suppresses expression of endodermal marker genes in the developing gut (Cell 91 (1997) 397). Here we show the effect of these manipulations on cell lineage. Expressing Xsox17 in a cells normally fated to become ectoderm causes their descendants either to relocate into the embryonic gut or to die at a late developmental stage. Conversely, disrupting Xsox17 activity in cells normally fated to be endodermal causes them to enter mesodermal and ectodermal lineages. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	MECHANISMS OF DEVELOPMENT
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0925-4773
Date:	December 2000
Volume:	99
Number:	1-2
Number of Pages:	6
Page Range:	pp. 65-70
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/12604

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