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Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin
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Vogeley, L., El Arnaout, T., Bailey, J., Stansfeld, Phillip J., Boland, C. and Caffrey, M. (2016) Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin. Science, 351 (6275). pp. 876-880. doi:10.1126/science.aad3747 ISSN 0036-8075.
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WRAP-structural-basis-lipoprotein-peptidase-globomycin-Stansfeld-2016.pdf - Accepted Version - Requires a PDF viewer. Download (1864Kb) | Preview |
Official URL: http://dx.doi.org/10.1126/science.aad3747
Abstract
Lipoproteins have key functions in many bacteria. They are synthesized in a precursor form that requires processing by enzymes that are essential in many pathogenic bacteria but have no equivalent in humans, making them potential drug targets. LspA is a key membrane protein involved in lipoprotein maturation in the bacterium Pseudomonas aeruginosa. Vogeley et al. determined the crystal structure of LspA bound to the antibiotic globomycin. Their structure and mutagenesis studies reveal how LspA processes substrate lipoproteins and indicate that globomycin inhibits the enzyme by binding to the active site. These findings should be useful in the development of new antibiotics.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology Q Science > QR Microbiology R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
Library of Congress Subject Headings (LCSH): | Lipoproteins , Peptide antibiotics, Pseudomonas aeruginosa, Crystals -- Structure | |||||||||
Journal or Publication Title: | Science | |||||||||
Publisher: | American Association for the Advancement of Science | |||||||||
ISSN: | 0036-8075 | |||||||||
Official Date: | 19 February 2016 | |||||||||
Dates: |
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Volume: | 351 | |||||||||
Number: | 6275 | |||||||||
Page Range: | pp. 876-880 | |||||||||
DOI: | 10.1126/science.aad3747 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Reuse Statement (publisher, data, author rights): | “This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 351(6275), 876-880. http://dx.doi.org/10.1126/science.aad3747 | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Copyright Holders: | Copyright © 2016, American Association for the Advancement of Science | |||||||||
Date of first compliant deposit: | 11 November 2019 | |||||||||
Date of first compliant Open Access: | 11 November 2019 | |||||||||
RIOXX Funder/Project Grant: |
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