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Functionalised peptidomimetic metallohelices
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Song, Hualong (2018) Functionalised peptidomimetic metallohelices. PhD thesis, University of Warwick.
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WRAP_Theses_Song_2018.pdf - Submitted Version - Requires a PDF viewer. Download (10Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b3403284~S15
Abstract
Chapter 1 introduces small host-defence peptides in cancer therapy. The main mechanisms proposed in their interactions with membranes and intracellular targets are discussed. The biologically relevant peptide mimetics are also reviewed.
Chapter 2 describes the synthesis and characterisation of alkyne derivatives of metallohelices. These alkyne metallohelices demonstrated promising anticancer activity in vitro. Investigations of click reactions on alkyne flexicates were partially successful.
Chapter 3 describes the click reaction of alkyne triplexes. A range of aromatic clicked triplexes were synthesized and characterised. These novel complexes showed potential anticancer activity and high selectivity, and antimetastatic properties. Preliminary mechanism study revealed these metallohelices inhibit Na+/K+ ATPase activity.
Chapter 4 describes two different methodologies to synthesize and characterise glycoconjugate metallohelices. A variety of glyco-metallohelices were then investigated for activity and selectivity in cancer cell lines and normal cell lines. The glyco-metallohelices displayed similar inhibition to the growth of human tumour xenografts, but lower side effect than cisplatin.
Chapter 5 focuses on the synthesis and characterisation of triplex metallohelices containing triazole ligands and their potential biological application.
Chapter 6 details the experimental procedures used to carry out the work in this thesis.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Cancer -- Treatment, Peptides, Organometallic compounds -- Synthesis | ||||
Official Date: | September 2018 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Department of Chemistry | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Scott, Peter | ||||
Sponsors: | China Scholarship Council | ||||
Format of File: | |||||
Extent: | 264 leaves : illustrations, charts | ||||
Language: | eng |
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