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Development of a routinely applicable imaging protocol for fast and precise middle cerebral artery occlusion assessment and perfusion deficit measure in an ovine stroke model : a case study
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Herrmann, Andrea M. , Cattaneo, Giorgio F. M., Eiden, Sebastian A. , Wieser, Manuela, Kellner, Elias, Maurer, Christoph, Haberstroh, Jörg, Mülling , Christoph, Niesen, Wolf-Dirk , Urbach, Horst, Boltze, Johannes, Meckel, Stephan and Shah, Mukesch Johannes (2019) Development of a routinely applicable imaging protocol for fast and precise middle cerebral artery occlusion assessment and perfusion deficit measure in an ovine stroke model : a case study. Frontiers in Neurology, 10 . 1113. doi:10.3389/fneur.2019.01113 ISSN 1664-2295.
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Official URL: https://doi.org/10.3389/fneur.2019.01113
Abstract
Temporary middle cerebral artery occlusion (MCAO) in sheep allows modeling of acute large vessel occlusion stroke and subsequent vessel recanalization. However, rapid and precise imaging-based assessment of vessel occlusion and the resulting perfusion deficit during MCAO still represents an experimental challenge. Here, we tested feasibility and suitability of a strategy for MCAO verification and perfusion deficit assessment. We also compared the extent of the initial perfusion deficit and subsequent lesion size for different MCAO durations. The rete mirabile prevents reliable vascular imaging investigation of middle cerebral artery filling status. Hence, computed tomography perfusion imaging was chosen for indirect confirmation of MCAO. Follow-up infarct size evaluation by diffusion-weighted magnetic resonance imaging revealed fluctuating results, with no apparent relationship of lesion size with MCAO at occlusion times below 4 h, potentially related to the variable collateralization of the MCA territory. This underlines the need for intra-ischemic perfusion assessment and future studies focusing on the correlation between perfusion deficit, MCAO duration, and final infarct volume. Temporary MCAO and intra-ischemic perfusion imaging nevertheless has the potential to be applied for the simulation of novel recanalization therapies, particularly those that aim for a fast reperfusion effect in combination with mechanical thrombectomy in a clinically realistic scenario.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Tomography, Cerebrovascular disease, Cerebral ischemia, Ischemia -- Pathophysiology, Reperfusion (Physiology), Clinical trials | ||||||
| Journal or Publication Title: | Frontiers in Neurology | ||||||
| Publisher: | Frontiers Research Foundation | ||||||
| ISSN: | 1664-2295 | ||||||
| Official Date: | 14 November 2019 | ||||||
| Dates: |
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| Volume: | 10 | ||||||
| Article Number: | 1113 | ||||||
| DOI: | 10.3389/fneur.2019.01113 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 8 October 2019 | ||||||
| Date of first compliant Open Access: | 8 October 2019 | ||||||
| RIOXX Funder/Project Grant: |
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