UNSPECIFIED (2000) The ELF3 zeitnehmer regulates light signalling to the circadian clock. Nature, 408 (6813). pp. 716-720. ISSN 0028-0836

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Abstract

The circadian system regulates 24-hour biological rhythms' and seasonal rhythms, such as flowering(2). Long-day flowering plants like Arabidopsis thaliana, measure day length with a rhythm that is not reset at lights-off(3), whereas short-day plants measure night length on the basis of circadian rhythm of light sensitivity that is set from dusk(2). early flowering 3 (elf3) mutants of Arabinopsis are aphotoperiodic(4) and exhibit light-conditional arrhythmia(5,6). Here we show that the elf3-7 mutant retains oscillator function in the light but blunts circadian gating of CAB gene activation, indicating that deregulated phototransduction may mask rhythmicity. Furthermore, elf3 mutations confer the resetting pattern of short-day photoperiodism, indicating that gating of phototransduction may control resetting. Temperature entrainment can bypass the requirement for normal ELF3 function for the oscillator and partially restore rhythmic CAB expression. Therefore, ELF3 specifically affects light input to the oscillator, similar to its function in gating CAB activation, allowing oscillator progression past a light-sensitive phase in the subjective evening. ELF3 provides experimental demonstration of the zeitnehmer ('time-taker') Concept(7,8).

Item Type:	Journal Article
Subjects:	Q Science
Journal or Publication Title:	Nature
Publisher:	MACMILLAN PUBLISHERS LTD
ISSN:	0028-0836
Date:	7 December 2000
Volume:	408
Number:	6813
Number of Pages:	5
Page Range:	pp. 716-720
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/12731

Data sourced from Thomson Reuters' Web of Knowledge

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