Szczepura, Ala, Freeman, Karoline, Osipenko, Leeza and Hyde, Julia (2005) Emerging prenatal genetic tests : developing a health technology assessment (HTA) framework for informed decision-making. [Coventry]: University of Warwick. (Initial report).

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Abstract

Delphi Process
In preparation for the first Delphi exercise, a list of questions was produced from the academic literature, webbased
sources and interviews with experts. These questions were structured into broad dimensions and a draft
questionnaire piloted. A final list of 73 questions formed the basis of the first Delphi survey. Participants were
asked to grade the perceived importance of each question for inclusion in HTA reports on new prenatal genetic
tests (4 = Essential; 3 = Desirable, but not essential; 2 = Useful but should not be required; 1 = Of little/ no
importance; 0 = I have no basis for judgement). Secondly, they were asked to indicate whether a question
should be addressed during test development or whether the question could be addressed later once the
technology is ready for implementation. Finally, Panel members were encouraged to identify any other questions
which appeared to be missing from the initial list. For copy of questionnaire, see Annex 1: Delphi Round 1
Questionnaire.
Respondents were also asked to provide personal details to give some indication of their HTA experience and
specialist expertise. Analysis of responses demonstrated that SAFE Delphi panel members represent a highly
experienced, multidisciplinary international group of experts with the knowledge required to define which key
questions should be addressed in HTA reports on new prenatal genetic tests.
Delphi Responses
Responses were received from 77/90 (86%) of Panel members. These were analysed with a cut-off of 75%
(±3%) applied as an indicator of Panel consensus for all questions. Thus, any question which three out of four
respondents rated as essential or desirable was retained, whilst those not achieving this level of agreement were
provisionally excluded. In addition, mean scores were also calculated (excluding 0 = I have no basis for
judgement) for each question. A mean score >3.25 ± 0.05 was taken as an indication that the Panel had
identified a particular question as being of the highest priority to address in HTA.

Item Type:	Report
Subjects:	R Medicine > RJ Pediatrics
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) > Warwick Evidence Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Prenatal diagnosis, Diagnosis, Noninvasive, Fetal cells from maternal blood
Series Name:	Initial report
Publisher:	University of Warwick
Place of Publication:	[Coventry]
ISBN:	0953543056
Official Date:	December 2005
Dates:	Date Event December 2005 Published
Number of Pages:	85
Status:	Not Peer Reviewed
Access rights to Published version:	Open Access
Description:	Final version (published as open access)
Funder:	Sixth Framework Programme (European Commission) (FP6)

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