UNSPECIFIED (2000) Real-time measurement of free radical production using specific electrochemical sensors: new insight into the consequences of O-2(-) and NO flux. ANALUSIS, 28 (6). pp. 493-505. ISSN 0365-4877

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Abstract

Direct real-time electrochemical measurements have offered new insight into the importance of free radical interplay in a number of cellular models, Initially the interrelationship between O-2(-) and NO generation in astrocytic, neuronal and mixed astrocytic/neuronal cell populations was examined. Results indicated a novel function for astrocytic nitric oxide synthase (cNOS) in regulating extracellular O-2(-) release and therefore controlling neuronal nitric oxide availability. Further, the pathological consequences of extracellular O-2(-) production on rat astrocytes was assessed, Findings show that extracellular O-2(-) generation initiated the production of NO by glial cells, Other findings facilitated by electrochemical measurements included the characterisation of a novel motor neuron like cell line for its ability to produce O-2(-) and NO in response to extracellular glutamate and AMPA, the interaction of O-2(-) with NO in an animal models of migraine headache and the modulatory effect of alpha -melanocyte stimulating hormone (alpha -MSH) on NO production by human epidermal melanocytes.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	ANALUSIS
Publisher:	E D P SCIENCES
ISSN:	0365-4877
Date:	July 2000
Volume:	28
Number:	6
Number of Pages:	13
Page Range:	pp. 493-505
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/12819

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