UNSPECIFIED (2000) Protective titres of measles neutralising antibody. JOURNAL OF MEDICAL VIROLOGY, 62 (4). pp. 511-517. ISSN 0146-6615

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Abstract

A nation-wide measles outbreak occurred in 1988 in Taiwan. A retrospective cohort study was conducted to define the protective titre of measles neutralising (NT) antibody. Paired sera collected in 1987 and 1988 were available from 190 individuals born in 1984 who had participated in an annual hepatitis B immunisation follow-up from 1986 to 1991. Measles NT titres were quantified using a standardised neutralisation enzyme immunoassay. Measles infection was defined as a greater than or equal to4-fold rise in NT titre or seroconversion between paired sera. Symptomatic measles infection was ascribed to individuals who had measles infection and who reported measles-like symptoms between 1987 and 1988. Results demonstrated a dose-response relationship between pre-exposure NT titres and protection against measles infection. 47 of 48 individuals with measles infection in 1988 had preexposure NT titres less than or equal to1,017 mlU/ml; all 12 symptomatic cases had pre-exposure NT titres less than or equal to 434 mlU/ml. Eleven vaccinees had preexposure NT titres <50 mlU/ml, of whom nine developed asymptomatic infection. The study suggests that measles NT titres >1,000 mlU/ml may prevent measles infection and NT titres >500 mlU/ml may prevent symptomatic infection but vaccinees with undetectable or low NT titres may not necessarily be susceptible to symptomatic infection. J. Med. Virol. 62:511-517, 2000. (C) 2000 Wiley-Liss, Inc.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF MEDICAL VIROLOGY
Publisher:	WILEY-LISS
ISSN:	0146-6615
Date:	December 2000
Volume:	62
Number:	4
Number of Pages:	7
Page Range:	pp. 511-517
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/12831

Data sourced from Thomson Reuters' Web of Knowledge

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