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A minimal model approach for the description of postprandial glucose responses from glucose sensor data in diabetes mellitus
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Eichenlaub, Manuel, Hattersley, John G. and Khovanova, N. A. (2019) A minimal model approach for the description of postprandial glucose responses from glucose sensor data in diabetes mellitus. In: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, 23-27 Jul 2019. Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) pp. 265-268. ISBN 9781538613115. doi:10.1109/EMBC.2019.8857195 ISSN 1558-4615.
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WRAP-minimal-model-description-postprandial-glucose-sensor-diabetes-Khovanova-2019.pdf - Accepted Version - Requires a PDF viewer. Download (1035Kb) | Preview |
Official URL: http://dx.doi.org/10.1109/EMBC.2019.8857195
Abstract
Modelling of the gluco-regulatory system in response to an oral glucose tolerance test (OGTT) has been the subject of research for decades. This paper presents an adaptation to the well-established oral minimal model that is identifiable from glucose data only and is able to capture the dynamics of glucose following both OGTT and mixed meal consumption. The model is in the form of low-dimensional differential equations with a recently introduced input function consisting of Gaussian shaped components. It was identified from glucose data recorded from six subjects without diabetes, prediabetes and type 2 diabetes under controlled conditions. The inferred parameters of the model are shown to have physiological meaning and produce realistic steady state behavior. This model may be useful in the development of clinical advisory tools for the treatment and prevention of non-insulin dependent type 2 diabetes mellitus.
| Item Type: | Conference Item (Paper) | ||||||
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| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
| Library of Congress Subject Headings (LCSH): | Glucose tolerance tests, Glucose tolerance tests -- Simulation methods , Blood sugar monitoring , Diabetes | ||||||
| Journal or Publication Title: | 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) | ||||||
| Publisher: | IEEE | ||||||
| ISBN: | 9781538613115 | ||||||
| ISSN: | 1558-4615 | ||||||
| Book Title: | 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) | ||||||
| Official Date: | 7 October 2019 | ||||||
| Dates: |
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| Page Range: | pp. 265-268 | ||||||
| DOI: | 10.1109/EMBC.2019.8857195 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Reuse Statement (publisher, data, author rights): | © 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Date of first compliant deposit: | 21 October 2019 | ||||||
| Date of first compliant Open Access: | 21 October 2019 | ||||||
| Conference Paper Type: | Paper | ||||||
| Title of Event: | 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) | ||||||
| Type of Event: | Conference | ||||||
| Location of Event: | Berlin, Germany | ||||||
| Date(s) of Event: | 23-27 Jul 2019 |
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