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Fog signaling has diverse roles in epithelial morphogenesis in insects

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Benton, Matthew Alan, Frey, Nadine, Nunes da Fonseca, Rodrigo , von Levetzow, Cornelia, Stappert, Dominik, Hakeemi, Muhammad Salim, Conrads, Kai H., Pechmann, Matthias, Panfilio, Kristen A., Lynch, Jeremy A. and Roth, Siegfried (2019) Fog signaling has diverse roles in epithelial morphogenesis in insects. eLife, 8 . e47346. doi:10.7554/elife.47346

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Official URL: https://doi.org/10.7554/elife.47346

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Abstract

The Drosophila Fog pathway represents one of the best-understood signaling cascades controlling epithelial morphogenesis. During gastrulation, Fog induces apical cell constrictions that drive the invagination of mesoderm and posterior gut primordia. The cellular mechanisms underlying primordia internalization vary greatly among insects and recent work has suggested that Fog signaling is specific to the fast mode of gastrulation found in some flies. On the contrary, here we show in the beetle Tribolium, whose development is broadly representative for insects, that Fog has multiple morphogenetic functions. It modulates mesoderm internalization and controls a massive posterior infolding involved in gut and extraembryonic development. In addition, Fog signaling affects blastoderm cellularization, primordial germ cell positioning, and cuboidal-to-squamous cell shape transitions in the extraembryonic serosa. Comparative analyses with two other distantly related insect species reveals that Fog’s role during cellularization is widely conserved and therefore might represent the ancestral function of the pathway.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QL Zoology
Divisions: Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Drosophila, Morphogenesis , Drosophila -- Morphogenesis , Gastrulation, Cellular signal transduction
Journal or Publication Title: eLife
Publisher: eLife Sciences Publications, Ltd
ISSN: 2050-084X
Official Date: 1 October 2019
Dates:
DateEvent
1 October 2019Published
30 September 2019Accepted
Volume: 8
Article Number: e47346
DOI: 10.7554/elife.47346
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: ** Article version: VoR ** From Crossref via Jisc Publications Router ** History: epub 01-10-2019; issued 01-10-2019. ** Licence for VoR version of this article starting on 01-10-2019: http://creativecommons.org/licenses/by/4.0/
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
CRC 680[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
UNSPECIFIEDUniversitätsklinikum KölnUNSPECIFIED
UNSPECIFIEDConselho Nacional de Desenvolvimento Científico e Tecnológicohttp://dx.doi.org/10.13039/501100003593
RU 1234[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
PhD fellowshipBoehringer Ingelheim Fondshttp://dx.doi.org/10.13039/501100001645
Emmy Noether Program PA 2044/1-1)[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
R03 HD078578National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
Postdoctoral FellowshipAlexander von Humboldt-Stiftunghttp://dx.doi.org/10.13039/100005156
407643416[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
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