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Fog signaling has diverse roles in epithelial morphogenesis in insects
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Benton, Matthew Alan, Frey, Nadine, Nunes da Fonseca, Rodrigo , von Levetzow, Cornelia, Stappert, Dominik, Hakeemi, Muhammad Salim, Conrads, Kai H., Pechmann, Matthias, Panfilio, Kristen A., Lynch, Jeremy A. and Roth, Siegfried (2019) Fog signaling has diverse roles in epithelial morphogenesis in insects. eLife, 8 . e47346. doi:10.7554/elife.47346
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Official URL: https://doi.org/10.7554/elife.47346
Abstract
The Drosophila Fog pathway represents one of the best-understood signaling cascades controlling epithelial morphogenesis. During gastrulation, Fog induces apical cell constrictions that drive the invagination of mesoderm and posterior gut primordia. The cellular mechanisms underlying primordia internalization vary greatly among insects and recent work has suggested that Fog signaling is specific to the fast mode of gastrulation found in some flies. On the contrary, here we show in the beetle Tribolium, whose development is broadly representative for insects, that Fog has multiple morphogenetic functions. It modulates mesoderm internalization and controls a massive posterior infolding involved in gut and extraembryonic development. In addition, Fog signaling affects blastoderm cellularization, primordial germ cell positioning, and cuboidal-to-squamous cell shape transitions in the extraembryonic serosa. Comparative analyses with two other distantly related insect species reveals that Fog’s role during cellularization is widely conserved and therefore might represent the ancestral function of the pathway.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QL Zoology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Drosophila, Morphogenesis , Drosophila -- Morphogenesis , Gastrulation, Cellular signal transduction | ||||||||||||||||||||||||||||||
| Journal or Publication Title: | eLife | ||||||||||||||||||||||||||||||
| Publisher: | eLife Sciences Publications, Ltd | ||||||||||||||||||||||||||||||
| ISSN: | 2050-084X | ||||||||||||||||||||||||||||||
| Official Date: | 1 October 2019 | ||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 8 | ||||||||||||||||||||||||||||||
| Article Number: | e47346 | ||||||||||||||||||||||||||||||
| DOI: | 10.7554/elife.47346 | ||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||
| Publisher Statement: | ** Article version: VoR ** From Crossref via Jisc Publications Router ** History: epub 01-10-2019; issued 01-10-2019. ** Licence for VoR version of this article starting on 01-10-2019: http://creativecommons.org/licenses/by/4.0/ | ||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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