The Library
NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis
Tools
Tools
Tools
Huang, R., Yuan, D. J., Li, S., Liang, X. S., Gao, Y., Lan, X. Y., Qin, H. M., Ma, Y. F., Xu, G. Y., Schachner, M., Sytnyk, V., Boltze, Johannes, Ma, Q. H. and Li, S. (2020) NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis. Journal of Cell Biology, 219 (1). e201902164. doi:10.1083/jcb.201902164
|
PDF
WRAP-NCAM-regulates-temporal-neural-progenitor-cells-corticogenesis-Boltze-2019.pdf - Accepted Version - Requires a PDF viewer. Download (1447Kb) | Preview |
Official URL: https://doi.org/10.1083/jcb.201902164
Abstract
The development of cerebral cortex requires spatially and temporally orchestrated proliferation, migration, and differentiation of neural progenitor cells (NPCs). The molecular mechanisms underlying cortical development are, however, not fully understood. The neural cell adhesion molecule (NCAM) has been suggested to play a role in corticogenesis. Here we show that NCAM is dynamically expressed in the developing cortex. NCAM expression in NPCs is highest in the neurogenic period and declines during the gliogenic period. In mice bearing an NPC-specific NCAM deletion, proliferation of NPCs is reduced, and production of cortical neurons is delayed, while formation of cortical glia is advanced. Mechanistically, NCAM enhances actin polymerization in NPCs by interacting with actin-associated protein profilin2. NCAM-dependent regulation of NPCs is blocked by mutations in the profilin2 binding site. Thus, NCAM plays an essential role in NPC proliferation and fate decision during cortical development by regulating profilin2-dependent actin polymerization.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Journal or Publication Title: | Journal of Cell Biology | ||||||||
| Publisher: | Rockefeller University Press | ||||||||
| ISSN: | 0021-9525 | ||||||||
| Official Date: | 6 January 2020 | ||||||||
| Dates: |
|
||||||||
| Date of first compliant deposit: | 25 October 2019 | ||||||||
| Volume: | 219 | ||||||||
| Number: | 1 | ||||||||
| Article Number: | e201902164 | ||||||||
| DOI: | 10.1083/jcb.201902164 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Publisher Statement: | ©2020 Huang et al. Originally published in Journal of Cell Biology. https://doi.org/10.1083/jcb.201902164 | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Copyright Holders: | © 2019 Huang et al. | ||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
