The Library
Simultaneous assessment of urinary and fecal volatile organic compound analysis in De Novo Pediatric IBD
Tools
Tools
Tools
el Manouni el Hassani, Sofia, Bosch, Sofie, Lemmen, Jesse P. M., Brizzio Brentar, Marina, Ayada, Ibrahim, Wicaksono, Alfian, Covington, James A., Benninga, Marc A., de Boer, Nanne K. H. and de Meij, Tim G. J. (2019) Simultaneous assessment of urinary and fecal volatile organic compound analysis in De Novo Pediatric IBD. Sensors, 19 (20). 4496. doi:10.3390/s19204496 ISSN 1424-8220.
|
PDF
WRAP-simultaneous-assessment-urinary-fecal-volatile-organic-analysis-pediatric-Covington-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (942Kb) | Preview |
Official URL: https://doi.org/10.3390/s19204496
Abstract
Endoscopic evaluation is mandatory in establishing the diagnosis of pediatric inflammatory bowel disease (IBD), but unfortunately carries a high burden on patients. Volatile organic compounds (VOC) have been proposed as alternative, noninvasive diagnostic biomarkers for IBD. The current study aimed to assess and compare the potential of fecal and urinary VOC as diagnostic biomarkers for pediatric IBD in an intention-to-diagnose cohort. In this cohort study, patients aged 4–17 years, referred to the outpatient clinic of a tertiary referral center under suspicion of IBD, were eligible to participate. The diagnosis was established by endoscopic and histopathologic assessment, participants who did not meet the criteria of IBD were allocated to the control group. Participants were instructed to concurrently collect a fecal and urinary sample prior to bowel lavage. Samples were analyzed by means of gas chromatography–ion mobility spectrometry. In total, five ulcerative colitis patients, five Crohn’s disease patients, and ten age and gender matched controls were included. A significant difference was demonstrated for both fecal (p-value, area under the curve; 0.038, 0.73) and urinary (0.028, 0.78) VOC profiles between IBD and controls. Analysis of both fecal and urinary VOC behold equal potential as noninvasive biomarkers for pediatric IBD diagnosis.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history R Medicine > RC Internal medicine T Technology > TD Environmental technology. Sanitary engineering |
||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Library of Congress Subject Headings (LCSH): | Volatile organic compounds , Biochemical markers, Inflammatory bowel diseases , Ion mobility spectroscopy, Gas chromatography | ||||||
| Journal or Publication Title: | Sensors | ||||||
| Publisher: | MDPI AG | ||||||
| ISSN: | 1424-8220 | ||||||
| Official Date: | 16 October 2019 | ||||||
| Dates: |
|
||||||
| Volume: | 19 | ||||||
| Number: | 20 | ||||||
| Article Number: | 4496 | ||||||
| DOI: | 10.3390/s19204496 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 29 October 2019 | ||||||
| Date of first compliant Open Access: | 29 October 2019 |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
