Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Modelling antibody response to measles vaccine and subsequent waning of immunity in a low exposure population

Tools
- Tools
+ Tools

UNSPECIFIED (2000) Modelling antibody response to measles vaccine and subsequent waning of immunity in a low exposure population. VACCINE, 19 (4-5). pp. 523-529. ISSN 0264-410X.

Research output not available from this repository.

Request-a-Copy directly from author or use local Library Get it For Me service.

Request Changes to record.

Abstract

We analysed measles antibody data from 1141 vaccinated Canadian children aged 4-16 years to investigate factors associated with seropositivity and magnitude of prevailing antibody titres. We used a mixed Bernoulli/log-gamma model which takes account of the possibility of primary vaccine failures, of censored observations due to the lower detection limit of antibody assays and of a potentially skewed distribution of the logarithm of titres, While controlling for all significant variables, we observed that measles antibody titres decline at a mean rate of 5.6% per annum (approximate 95% CI; 3.3-7.7) equivalent to a half life of 12 years. Further, we noted a detectable linear relationship with respect to age at immunisation such that the mean increase in measles antibody titre of an infant who responds to vaccination gained by delaying vaccination from 12 to Is months of age is 11.1% (approximate 95% CI; 4.4-18.3). (C) 2000 Elsevier Science Ltd. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine
Journal or Publication Title: VACCINE
Publisher: ELSEVIER SCI LTD
ISSN: 0264-410X
Official Date: 15 October 2000
Dates:
DateEvent
15 October 2000UNSPECIFIED
Volume: 19
Number: 4-5
Number of Pages: 7
Page Range: pp. 523-529
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us