Defective deletion mutant amplification
UNSPECIFIED (2000) Defective deletion mutant amplification. JOURNAL OF THEORETICAL BIOLOGY, 206 (4). pp. 449-464. ISSN 0022-5193Full text not available from this repository.
Defective deletion mutants can be replicated in superinfected cells by parasitism of the intact virus' replication machinery, and through replication with the host cell. We show by analysis of a mathematical model that dynamic stability of superinfected cell growth is crucial in determining the frequency of deletion mutant infected cells, i.e. there is a critical infectivity threshold rho (sc) below which the density of proliferative virus is significantly reduced by the presence of defective deletion mutants. Above rho (sc), proliferative virus principally occurs as superinfected cells (wild type with defective deletion mutant). The threshold rho (sc), and the interference effects of the deletion mutant, increase with deletion mutant parasitism of the wild-type replication machinery in superinfected cells. The interaction of virally infected cells with host homeostasis determines whether immune escape by deletion mutant infected cells is necessary for the interference window to exist. Only when the deletion mutant has a detrimental effect on infected host cell replication did we observe periodic behaviour. (C) 2000 Academic Press.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Journal or Publication Title:||JOURNAL OF THEORETICAL BIOLOGY|
|Publisher:||ACADEMIC PRESS LTD|
|Date:||21 October 2000|
|Number of Pages:||16|
|Page Range:||pp. 449-464|
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