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Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis
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Guy, Collette S., Murray, Kathryn, Gibson, Matthew I. and Fullam, Elizabeth (2019) Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis. Organic & Biomolecular Chemistry, 17 (43). pp. 9524-9528. doi:10.1039/C9OB02222H ISSN 1477-0520.
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Official URL: http://dx.doi.org/10.1039/C9OB02222H
Abstract
Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need to cross the impermeable mycobacterial cell envelope barrier.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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Library of Congress Subject Headings (LCSH): | Multidrug-resistant tuberculosis -- Prevention, Tuberculosis , Tuberculosis -- Prevention, Mycobacterium tuberculosis | |||||||||||||||||||||
Journal or Publication Title: | Organic & Biomolecular Chemistry | |||||||||||||||||||||
Publisher: | Royal Society of Chemistry | |||||||||||||||||||||
ISSN: | 1477-0520 | |||||||||||||||||||||
Official Date: | 2019 | |||||||||||||||||||||
Dates: |
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Volume: | 17 | |||||||||||||||||||||
Number: | 43 | |||||||||||||||||||||
Page Range: | pp. 9524-9528 | |||||||||||||||||||||
DOI: | 10.1039/C9OB02222H | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 30 October 2019 | |||||||||||||||||||||
Date of first compliant Open Access: | 31 October 2019 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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