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Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis
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Guy, Collette S., Murray, Kathryn, Gibson, Matthew I. and Fullam, Elizabeth (2019) Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis. Organic & Biomolecular Chemistry, 17 (43). pp. 9524-9528. doi:10.1039/C9OB02222H
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Official URL: http://dx.doi.org/10.1039/C9OB02222H
Abstract
Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need to cross the impermeable mycobacterial cell envelope barrier.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Chemistry Faculty of Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Multidrug-resistant tuberculosis -- Prevention, Tuberculosis , Tuberculosis -- Prevention, Mycobacterium tuberculosis | |||||||||||||||||||||
| Journal or Publication Title: | Organic & Biomolecular Chemistry | |||||||||||||||||||||
| Publisher: | Royal Society of Chemistry | |||||||||||||||||||||
| ISSN: | 1477-0520 | |||||||||||||||||||||
| Official Date: | 2019 | |||||||||||||||||||||
| Dates: |
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| Volume: | 17 | |||||||||||||||||||||
| Number: | 43 | |||||||||||||||||||||
| Page Range: | pp. 9524-9528 | |||||||||||||||||||||
| DOI: | 10.1039/C9OB02222H | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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