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Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

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Guy, Collette S., Murray, Kathryn, Gibson, Matthew I. and Fullam, Elizabeth (2019) Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis. Organic & Biomolecular Chemistry, 17 (43). pp. 9524-9528. doi:10.1039/C9OB02222H

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Official URL: http://dx.doi.org/10.1039/C9OB02222H

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Abstract

Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need to cross the impermeable mycobacterial cell envelope barrier.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Multidrug-resistant tuberculosis -- Prevention, Tuberculosis , Tuberculosis -- Prevention, Mycobacterium tuberculosis
Journal or Publication Title: Organic & Biomolecular Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1477-0520
Official Date: 2019
Dates:
DateEvent
2019Published
29 October 2019Available
16 October 2019Accepted
Volume: 17
Number: 43
Page Range: pp. 9524-9528
DOI: 10.1039/C9OB02222H
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MR/N006917/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
EP/M027503/[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
Sir Henry Dale fellowshipWellcome Trusthttp://dx.doi.org/10.13039/100010269
104193/Z/14/[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
78918H2020 European Research Councilhttp://dx.doi.org/10.13039/100010663
BB/L024209/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268

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