UNSPECIFIED (2000) Fc gamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups. ARTHRITIS AND RHEUMATISM, 43 (10). pp. 2328-2334. ISSN 0004-3591

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Abstract

Objective. To investigate a possible association between a functional polymorphism in the intermediate-affinity receptor for IgG called Fc gamma receptor type IIIA (Fc gamma RIIIA [CD16]) and rheumatoid arthritis (RA), Methods. This was an allelic association study in which a single nucleotide polymorphism in Fc gamma RIIIA was examined as a susceptibility and/or severity factor for RA, The Fc gamma RIIIA-158V/F polymorphism was genotyped by direct sequencing in 2 well-characterized ethnic groups, UK Caucasians (141 RA patients and 124 controls) and North Indians and Pakistanis (108 RA patients and 113 controls). Results. The Fc gamma RIIIA-158V/F polymorphism was associated with RA in both ethnic groups (P = 0.028 for UK Caucasians, P = 0.050 for North Indians and Pakistanis, and P = 0.003 for both groups combined). Fc gamma RIIIA-158VF and -158VV individuals had an increased risk of developing RA in both populations (UK Caucasians odds ratio [OR] 1.6, P = 0.050; North Indians and Pakistanis OR 1.9, P = 0.023; and combined groups OR 1.7, P = 0.003). In the UK Caucasian group, the highest risk was for nodular RA, a more severe disease subset, associated with homozygosity for the Fc gamma RIIIA-158V allele (OR 4.4, P = 0.004). There was also evidence for an interaction between the RA-associated HLA-DRB1 allele and the presence of at least 1 Fc gamma RIIIA-158V allele in predicting susceptibility to RA (OR 5.5, P = 0.000). Conclusion. We have demonstrated that the Fc gamma RIIIA-158V/F polymorphism is a susceptibility and/or severity marker for RA. in 2 distinct ethnic groups. This finding may ultimately provide additional insights into the pathogenesis of RA and other autoantibody/immune complex-driven autoimmune diseases.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Journal or Publication Title:	ARTHRITIS AND RHEUMATISM
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	0004-3591
Date:	October 2000
Volume:	43
Number:	10
Number of Pages:	7
Page Range:	pp. 2328-2334
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/12899

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