Fc gamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups
UNSPECIFIED. (2000) Fc gamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups. ARTHRITIS AND RHEUMATISM, 43 (10). pp. 2328-2334. ISSN 0004-3591Full text not available from this repository.
Objective. To investigate a possible association between a functional polymorphism in the intermediate-affinity receptor for IgG called Fc gamma receptor type IIIA (Fc gamma RIIIA [CD16]) and rheumatoid arthritis (RA),
Methods. This was an allelic association study in which a single nucleotide polymorphism in Fc gamma RIIIA was examined as a susceptibility and/or severity factor for RA, The Fc gamma RIIIA-158V/F polymorphism was genotyped by direct sequencing in 2 well-characterized ethnic groups, UK Caucasians (141 RA patients and 124 controls) and North Indians and Pakistanis (108 RA patients and 113 controls).
Results. The Fc gamma RIIIA-158V/F polymorphism was associated with RA in both ethnic groups (P = 0.028 for UK Caucasians, P = 0.050 for North Indians and Pakistanis, and P = 0.003 for both groups combined). Fc gamma RIIIA-158VF and -158VV individuals had an increased risk of developing RA in both populations (UK Caucasians odds ratio [OR] 1.6, P = 0.050; North Indians and Pakistanis OR 1.9, P = 0.023; and combined groups OR 1.7, P = 0.003). In the UK Caucasian group, the highest risk was for nodular RA, a more severe disease subset, associated with homozygosity for the Fc gamma RIIIA-158V allele (OR 4.4, P = 0.004). There was also evidence for an interaction between the RA-associated HLA-DRB1 allele and the presence of at least 1 Fc gamma RIIIA-158V allele in predicting susceptibility to RA (OR 5.5, P = 0.000).
Conclusion. We have demonstrated that the Fc gamma RIIIA-158V/F polymorphism is a susceptibility and/or severity marker for RA. in 2 distinct ethnic groups. This finding may ultimately provide additional insights into the pathogenesis of RA and other autoantibody/immune complex-driven autoimmune diseases.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Journal or Publication Title:||ARTHRITIS AND RHEUMATISM|
|Publisher:||LIPPINCOTT WILLIAMS & WILKINS|
|Official Date:||October 2000|
|Number of Pages:||7|
|Page Range:||pp. 2328-2334|
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