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A photoactivatable small molecule probe for the in vivo capture of polyketide intermediates
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Tosin, Manuela, Kilgour, Samantha Louise and Jenkins, Robert (2019) A photoactivatable small molecule probe for the in vivo capture of polyketide intermediates. Chemistry – A European Journal, 25 (72). pp. 16511-16514. doi:10.1002/chem.201903661 ISSN 1521-3765.
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Official URL: http://dx.doi.org/10.1002/chem.201903661
Abstract
A photolabile carba(dethia) malonyl N‐acetylcysteamine derivative was devised and prepared for the trapping of biosynthetic polyketide intermediates following light activation. From the lasalocid A polyketide assembly in a mutant strain of the soil bacterium S. lasaliensis, a previously undetected cyclised intermediate was identified and characterised, providing a new outlook on the timing of substrate processing.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Journal or Publication Title: | Chemistry – A European Journal | ||||||||
Publisher: | Wiley | ||||||||
ISSN: | 1521-3765 | ||||||||
Official Date: | 20 December 2019 | ||||||||
Dates: |
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Volume: | 25 | ||||||||
Number: | 72 | ||||||||
Page Range: | pp. 16511-16514 | ||||||||
DOI: | 10.1002/chem.201903661 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | "This is the peer reviewed version of the following article: Tosin, Manuela, Kilgour, Samantha Louise and Jenkins, Robert (2019) A photoactivatable small molecule probe for the in vivo capture of polyketide intermediates. Chemistry – A European Journal . (In Press), which has been published in final form at doi:10.1002/chem.201903661. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 7 November 2019 | ||||||||
Date of first compliant Open Access: | 20 November 2019 |
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