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Plasma proteomic approach in patients with heart failure : insights into pathogenesis of disease progression and potential novel treatment targets
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(2020) Plasma proteomic approach in patients with heart failure : insights into pathogenesis of disease progression and potential novel treatment targets. European Journal of Heart Failure, 22 (1). pp. 70-80. doi:10.1002/ejhf.1608
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WRAP-plasma-proteomic-patients-heart-failure-disease-novel-targets-Mohan-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (6Mb) | Preview |
Official URL: http://dx.doi.org/10.1002/ejhf.1608
Abstract
Aims
To provide insights into pathogenesis of disease progression and potential novel treatment targets for patients with heart failure by investigation of the plasma proteome using network analysis.
Methods and results
The plasma proteome of 50 patients with heart failure who died or were rehospitalised were compared with 50 patients with heart failure, matched for age and sex, who did not have an event. Peptides were analysed on two‐dimensional liquid chromatography coupled to tandem mass spectrometry (2D LC ESI‐MS/MS) in high definition mode (HDMSE). We identified and quantified 3001 proteins, of which 51 were significantly up‐regulated and 46 down‐regulated with more than two‐fold expression changes in those who experienced death or rehospitalisation. Gene ontology enrichment analysis and protein–protein interaction networks of significant differentially expressed proteins discovered the central role of metabolic processes in clinical outcomes of patients with heart failure. The findings revealed that a cluster of proteins related to glutathione metabolism, arginine and proline metabolism, and pyruvate metabolism in the pathogenesis of poor outcome in patients with heart failure who died or were rehospitalised.
Conclusions
Our findings show that in patients with heart failure who died or were rehospitalised, the glutathione, arginine and proline, and pyruvate pathways were activated. These pathways might be potential targets for therapies to improve poor outcomes in patients with heart failure.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Heart failure , Heart -- Diseases , Heart -- Diseases -- Treatment , Plasma spectroscopy , Proteomics | ||||||||||||||||||
| Journal or Publication Title: | European Journal of Heart Failure | ||||||||||||||||||
| Publisher: | John Wiley & Sons Ltd. | ||||||||||||||||||
| ISSN: | 1388-9842 | ||||||||||||||||||
| Official Date: | January 2020 | ||||||||||||||||||
| Dates: |
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| Volume: | 22 | ||||||||||||||||||
| Number: | 1 | ||||||||||||||||||
| Page Range: | pp. 70-80 | ||||||||||||||||||
| DOI: | 10.1002/ejhf.1608 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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