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Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism
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UNSPECIFIED (2000) Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. NEUROREPORT, 11 (13). pp. 2931-2935. ISSN 0959-4965.
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Abstract
In this study we report a convergence of behavioural and neuroanatomical evidence in support of an amygdala hypothesis of autism. We find that people with high-functioning autism (HFA) show neuropsychological profiles characteristic of the effects of amygdala damage, in particular selective impairment in the recognition of facial expressions of fear, perception of eye-gaze direction, and recognition memory for faces. Using quantitative magnetic resonance (MR) image analysis techniques, we find that the same individuals also show abnormalities of medial temporal lobe (MTL) brain structure, notably bilaterally enlarged amygdala volumes. These results combine to suggest that developmental malformation of the amygdala may underlie the social-cognitive impairments characteristic of HFA. This malformation may reflect incomplete neuronal pruning in early development. NeuroReport 11:2931-2935 (C) 2000 Lippincott Williams & Wilkins.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
| Journal or Publication Title: | NEUROREPORT | ||||
| Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||
| ISSN: | 0959-4965 | ||||
| Official Date: | 11 September 2000 | ||||
| Dates: |
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| Volume: | 11 | ||||
| Number: | 13 | ||||
| Number of Pages: | 5 | ||||
| Page Range: | pp. 2931-2935 | ||||
| Publication Status: | Published |
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