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Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism

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UNSPECIFIED (2000) Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. NEUROREPORT, 11 (13). pp. 2931-2935. ISSN 0959-4965.

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Abstract

In this study we report a convergence of behavioural and neuroanatomical evidence in support of an amygdala hypothesis of autism. We find that people with high-functioning autism (HFA) show neuropsychological profiles characteristic of the effects of amygdala damage, in particular selective impairment in the recognition of facial expressions of fear, perception of eye-gaze direction, and recognition memory for faces. Using quantitative magnetic resonance (MR) image analysis techniques, we find that the same individuals also show abnormalities of medial temporal lobe (MTL) brain structure, notably bilaterally enlarged amygdala volumes. These results combine to suggest that developmental malformation of the amygdala may underlie the social-cognitive impairments characteristic of HFA. This malformation may reflect incomplete neuronal pruning in early development. NeuroReport 11:2931-2935 (C) 2000 Lippincott Williams & Wilkins.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Journal or Publication Title: NEUROREPORT
Publisher: LIPPINCOTT WILLIAMS & WILKINS
ISSN: 0959-4965
Official Date: 11 September 2000
Dates:
DateEvent
11 September 2000UNSPECIFIED
Volume: 11
Number: 13
Number of Pages: 5
Page Range: pp. 2931-2935
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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