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Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water
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Rho, Julia Y., Cox, Henry, Mansfield, Edward D. H., Ellacott, Sean H., Peltier, Raoul, Brendel, Johannes C., Hartlieb, Matthias, Waigh, Thomas A. and Perrier, Sébastien (2019) Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water. Nature Communications, 10 (1). 4708. doi:10.1038/s41467-019-12586-8 ISSN 2041-1723.
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Official URL: https://doi.org/10.1038/s41467-019-12586-8
Abstract
Self-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them highly dynamic and prone to disassembly at the low concentration needed for biological applications. Here we demonstrate that a secondary hydrophobic interaction, near the peptide core, can stabilise the highly dynamic peptide bonds, without losing the vital solubility of the systems in aqueous conditions. This hierarchical self-assembly process can be used to stabilise a range of different β-sheet hydrogen bonded architectures.
| Item Type: | Journal Article | |||||||||||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Self-assembly (Chemistry) , Peptides, Nanotubes -- Solubility, Nanotubes | |||||||||||||||||||||||||||
| Journal or Publication Title: | Nature Communications | |||||||||||||||||||||||||||
| Publisher: | Nature Publishing Group | |||||||||||||||||||||||||||
| ISSN: | 2041-1723 | |||||||||||||||||||||||||||
| Official Date: | 17 October 2019 | |||||||||||||||||||||||||||
| Dates: |
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| Volume: | 10 | |||||||||||||||||||||||||||
| Number: | 1 | |||||||||||||||||||||||||||
| Article Number: | 4708 | |||||||||||||||||||||||||||
| DOI: | 10.1038/s41467-019-12586-8 | |||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | ** From Europe PMC via Jisc Publications Router ** History: ppub 01-10-2019; epub 17-10-2019. ** Licence for this article: cc by | |||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
| Date of first compliant deposit: | 2 December 2019 | |||||||||||||||||||||||||||
| Date of first compliant Open Access: | 4 December 2019 | |||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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