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Fluorescent supramolecular polymersomes based on pillararene/paraquat molecular recognition for pH-controlled drug release
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Zhao, Run, Zhou, Yu-Juan, Jie, Ke-Cheng, Yang, Jie, Perrier, Sébastien and Huang, Fei-He (2020) Fluorescent supramolecular polymersomes based on pillararene/paraquat molecular recognition for pH-controlled drug release. Chinese Journal of Polymer Science, 38 . pp. 1-8. doi:10.1007/s10118-019-2305-1 ISSN 0256-7679.
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WRAP-Fluorescent-supramolecular-polymersomes-pillararene-drug-Perrier-2019.pdf - Accepted Version - Requires a PDF viewer. Download (1840Kb) | Preview |
Official URL: http://dx.doi.org/10.1007/s10118-019-2305-1
Abstract
Researchers have put significant efforts on developing versatile fluorescent polymeric systems due to their promising biological/biomedical labelling, tracking, monitoring, imaging, and diagnostic applications. However, complicated organic/polymeric synthesis or post-modification of these functionalized platforms is still a big obstacle for their further application and thereby provides clear motivation for exploring alternative strategies for the design and fabrication of easily available fluorescent systems. The marriage of supramolecular polymers and fluorescent imaging can provide a facile and dynamic manner instead of tedious and time-consuming synthesis due to the dynamic and reversible nature of noncovalent interactions. Herein, based on water-soluble pillararene/paraquat molecular recognition, we successfully prepare two amphiphilic polypseudorotaxanes which can self-assemble into supramolecular polymersomes in water. These polymersomes can be reversibly destroyed and reformed by tuning the solution pH. Attributed to the aggregation-induced emission of tetraphenylethylene groups, intense fluorescence can be introduced into the obtained supramolecular polymersomes. Furthermore, pH-triggered release of an encapsulated water-insoluble drug (doxorubicin) from the self-assembled fluorescent supramolecular polymersomes is also investigated.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QC Physics Q Science > QD Chemistry R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Drug delivery systems , Polymers in medicine, Polymers, Polymerization | ||||||||
| Journal or Publication Title: | Chinese Journal of Polymer Science | ||||||||
| Publisher: | Springer | ||||||||
| ISSN: | 0256-7679 | ||||||||
| Official Date: | January 2020 | ||||||||
| Dates: |
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| Volume: | 38 | ||||||||
| Page Range: | pp. 1-8 | ||||||||
| DOI: | 10.1007/s10118-019-2305-1 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | This is a post-peer-review, pre-copyedit version of an article published in Chinese Journal of Polymer Science. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10118-019-2305-1 | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 2 December 2019 | ||||||||
| Date of first compliant Open Access: | 27 September 2020 |
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