Constitutive and acquired resistance to calcineurin inhibitors in renal transplantation: role of P-glycoprotein-170
UNSPECIFIED. (2000) Constitutive and acquired resistance to calcineurin inhibitors in renal transplantation: role of P-glycoprotein-170. TRANSPLANT INTERNATIONAL, 13 (4). pp. 276-284. ISSN 0934-0874Full text not available from this repository.
The present study examines whether resistance to Cyclosporin A (CyA) and Tacrolimus (FK506) develops in Tcells from individual patients and the role of P-glycoprotein 170 (P-gp) in mediating drug resistance. IC(50)s were established for CyA and FK506 in cell cultures from 46 renal allograft recipients. P-gp expression and functional activity were determined by flow cytometry. Mean LD,, for CyA was 29 mu g/li (range 2.5-100) and for FK5061.2 mu g/li (range 0.085-5.5). The sensitivities to the two drugs were correlated (P = 0.0001). There was variation in the ratio of the ID(50)s depending on the drug used for treatment (P = 0.02). There was no difference in P-gp expression and functional activity in patients with sensitive or resistant cells. The data indicate an association between the sensitivities to CyA and FK506 and evidence of selective resistance to whichever drug was used. P-gp drug transport does not explain this variation.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RD Surgery|
|Journal or Publication Title:||TRANSPLANT INTERNATIONAL|
|Number of Pages:||9|
|Page Range:||pp. 276-284|
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