UNSPECIFIED. (2000) The effects of placental extracts from normotensive and preeclamptic women on vasoconstriction and oxidative metabolism. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 183 (1). pp. 206-210. ISSN 0002-9378

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Abstract

OBJECTIVE: A circulating factor derived from the placenta has been implicated in the pathogenesis of preeclampsia. The aim of this study was to determine whether placental extracts from normotensive women and women with preeclampsia increase oxidative metabolism and histamine-induced vasoconstriction in porcine carotid artery. STUDY DESIGN: Placental extracts from normotensive women and women with preeclampsia were applied to porcine carotid artery, and oxidative metabolism was measured. Histamine-induced isometric force responses were also determined in the absence and presence of placental extracts. RESULTS: Application of placental extracts to porcine carotid artery caused a fall in oxygen tension. which reflects increased consumption. Extracts from placentas taken from women with preeclampsia caused a greater fall than those from normotensive women (0.117 +/- 0.026 vs 0.018 +/- 0.0024 mu mol oxygen per milligram; P less than or equal to .01). Histamine-induced contractions were potentiated by extracts from preeclampsia but not from those of women without hypertension. The maximal steady-state force values were 13,137 +/- 3647, 12,921 +/- 3684, and 21,673 +/- 7189 N/m(-2) for control, normotensive, and preeclamptic samples at 10-mu mol/L histamine (P less than or equal to .05, compared with control placental extracts). CONCLUSIONS: Placental extracts from women with preeclampsia cause a greater stimulation of porcine artery oxygen consumption and exacerbation of histamine-induced vasoconstriction than extracts from normotensive women.

Item Type:	Journal Article
Subjects:	R Medicine > RG Gynecology and obstetrics
Journal or Publication Title:	AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Publisher:	MOSBY, INC
ISSN:	0002-9378
Date:	July 2000
Volume:	183
Number:	1
Number of Pages:	5
Page Range:	pp. 206-210
Identification Number:	10.1067/mob.2000.105584
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/13144

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