Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Plerixafor-aided mobilization of peripheral blood hematopoietic stem cells to support subsequent high-dose chemotherapy after a prior autologous transplant

Tools
- Tools
+ Tools

Fergadis, Evangelos, Assi, Abraam, Kranidioti, Eleftheria, Kosma, Aikaterini, Karakosta, Maria, Miltiadous, Constantinos, Dimitriadis, Georgios K., Grivas, Anastasios, Athanasopoulos, Aggelos, Lianos, Evangelos and Kosmas, Christos (2020) Plerixafor-aided mobilization of peripheral blood hematopoietic stem cells to support subsequent high-dose chemotherapy after a prior autologous transplant. Clinical Lymphoma Myeloma and Leukemia, 20 (2). E50-E57. doi:10.1016/j.clml.2019.11.022

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1016/j.clml.2019.11.022

Request Changes to record.

Abstract

Background:
An appreciable proportion of patients in need of salvage high-dose chemotherapy (HDC) and autologous peripheral blood stem cell (PBSC) transplantation (PBSCT) fail to mobilize adequate numbers of hematopoietic progenitors, and plerixafor is applied for that purpose. Limited data exist on remobilization of PBSCs in patients who have relapsed after prior HDC + PBSCT. Herein, we report on consecutive patients that had undergone successful prior single or tandem HDC for a variety of malignant neoplasms in our institution, and later required re-mobilization of PBSCs in order to support further HDC cycles.

Patients and Methods:
Plerixafor was administered in combination with granulocyte-colony stimulating factor alone, or after mobilizing chemotherapy. Five patients, 2 B-cell non-Hodgkin lymphomas, 1 multiple myeloma, 1 germ-cell tumor, and 1 Ewing sarcoma, having relapsed after prior HDC + PBSCT, were deemed candidates for further cycle(s) of PBSC-supported HDC. Plerixafor was applied in a “just-in-time” strategy after low CD34+ numbers were measured on the first day of anticipated hematopoietic stem cell collection (non-Hodgkin lymphoma, germ-cell tumor, and Ewing sarcoma), or pre-emptively in multiple myeloma.

Results:
Successful collection of adequate PBSCs was achieved in all patients, from 1.8 to 3.8 × 106/kg after a median of 2 (range, 1-3) leukaphereses; 4 of 5 patients underwent subsequent HDC + PBSCT and engrafted after a median of 11 days (range, 9-55 days) and 25 days (range, 17-76 days) for neutrophils and platelets, respectively.

Conclusion:
Plerixafor proved effective to mobilize adequate numbers of PBSCs in individual patients with relapsed malignancies after prior single or tandem HDC + PBSCT. These PBSCs could establish sustained multi-lineage hematopoietic engraftment without any sequelae.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Clinical Lymphoma Myeloma and Leukemia
Publisher: Elsevier Inc.
ISSN: 2152-2650
Official Date: February 2020
Dates:
DateEvent
February 2020Published
5 December 2019Available
28 November 2019Accepted
Volume: 20
Number: 2
Page Range: E50-E57
DOI: 10.1016/j.clml.2019.11.022
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us